Andrew Huberman· PhD
It's also known as the Horvath clock. It's the biological clock. It's separate from your chronological age. There are some people that are 10-20 years younger than other people biologically.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
It's also known as the Horvath clock. It's the biological clock. It's separate from your chronological age. There are some people that are 10-20 years younger than other people biologically.
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This epigenetic testing consistently proved remarkably predictive, aligning closely with other health markers.
Cheek DNA methylation noise is shown to predict chronological age, consistent with ITOA.
Compared with age-prediction models based on biochemical markers, their methylation clock demonstrated superior performance, non-linear aging rates and sex-specific differences
Using a few hundred DNA methylation sites, blood-based epigenetic clock by Hannum & the multi-tissue clock by Horvath yield age estimates with a correlation to your age above r=0.9 🧬
Our method uses a combination of machine learning computations to figure out which DNA methylation sites (and how many) are the best to measure in order to estimate someone’s epigenetic (biological) age
oh I don't know what the latest statistics are for a human blood sample it was 95% accurate for chronologically.
And if you gave me a sample of an embryo or a baby or a teenage girl or an 80 year old i and some other labs in the world can read that DNA and by the pattern I could tell you exactly the age of that cell or that tissue.
for people between about 20 and 80 there's a stereotypical change in methylation patterns on dna and this is just a chemical change to dna that happens over time that's quite characteristic of your chronologic age
by looking at the methylation pattern on peripheral blood leukocyte dna we can tell how old you are within about six months to a year and this has been replicated by several groups
so i think if you get to the point where you can understand mechanism it's going to be much more powerful
so what has been observed um in laboratory animals and in humans is that there are changes in these epigenetic marks that happen in a predictable way with age and there are tens of thousands of these marks that can be measured you know at any given time um in a cell and that you can create algorithms that are that that predict the age related changes in these epigenetic marks with a pretty high degree of accuracy so you can you can sample a subset of these specific chemical changes um and come up with an algorithm that within you know plus or minus five years will predict a person or an animal's chronological age
so what the the idea that has emerged from that is you can do that at the population level and then if you identify individuals whose chronological age doesn't match up really perfectly well with their epigenetic age in other words they lie off of that best fit line that those people may be biologically younger or older than their chronological age
what the the idea that has emerged from that is you can do that at the population level and then if you identify individuals whose chronological age doesn't match up really perfectly well with their epigenetic age in other words they lie off of that best fit line that those people may be biologically younger or older than their chronological age and so that's where this idea of these epigenetic clocks has come from is you then at least in principle can predict a person's biological age depending on how well they fit the best fit line for this this algorithm
what has been observed um in laboratory animals and in humans is that there are changes in these epigenetic marks that happen in a predictable way with age and there are tens of thousands of these marks that can be measured you know at any given time in a cell and that you can create algorithms that are that predict the age-related changes in these epigenetic marks with a pretty high degree of accuracy so you can you can sample a subset of these specific chemical changes um and come up with an algorithm that within you know plus or minus five years will predict a person or an animal's chronological age
New article on epigenetic aging clocks! Learn how various epigenetic clocks can predict chronological age, biological age & can even predict mortality!
And they've done this in people. They've taken blood cells, from young individuals and old, you know, different ages, and they've seen there's patterns, methylation patterns, for example. And they can take a blood cell from a person and guess their age, and they get within five years, plus or minus, which is quite striking to me.
predict first chronological age with pretty 96 or so accuracy yes and so you know obviously they're while they're while they're stable at the same time they are changing yes
Because again, chronological age is just an imperfect proxy of this process that we actually care about, that, you know, is why people get diseases when they get older, why people die when they get older. So, if you can actually quantify the process as best as possible, it's better than chronological age.