Andrew Huberman· PhD
So exercise will do it, fasting will do it.
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So exercise will do it, fasting will do it.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
We showed, now going back to 2005, that fasting activates the sirtuins, and later, we showed exercise activates these genes. So a lot of the things that were told by doctors to do, to live longer and be healthier, we think acts through the sirtuins, in concert with these other two sets of genes we just talked about.
why would you take resveratrol for instance well you might take it because you wanted to activate the certain genes for longevity well guess what fasting does the same thing heat does the same thing coal does the same thing you can get all of these genes activated by exercising by doing these things
why would you take resveratrol for instance well you might take it because you wanted to activate the sirtuin genes for longevity well guess what fasting does the same thing heat does the same thing coal does the same thing you can get all of these genes activated by exercising by doing these things
Time-restricted eating produces fat loss independent of total calories.
A 72-hour fast measurably improves autophagy markers in healthy adults.
One-meal-a-day (OMAD) eating patterns increase all-cause mortality in long-running cohort data.
Eating the largest meal before 3pm improves 24-hour glucose vs. an evening-heavy schedule, calorie-matched.