Decreasing IGF-1 and growth hormone levels in mice, worms, and flies leads to a 50% extension in lifespan, while overexpressing them reduces lifespan by 50%.

“Going back to the original studies of Cynthia Kenyon, which we talked about in episode one, those mutant worms had low levels of growth hormone and insulin like growth hormone signaling. Twice as long. And this has been reproduced also in mice. And even in humans, there are the Loren dwarfs, we were talking about earlier. These are smaller people that have low levels of growth hormone, or actually IGF-1, one of”

“the small dogs live longer yes and the ponies live longer and when you mutate growth Ramone or or they are born dwarf they live longer and when you give more growth hormone they live shorter”

“in mice in worms and in flies decreasing igf-1 and growth hormone levels leads to a 50% extension in lifespan that's huge and the converse is true if you overexpress or increase the expression of growth hormone between 100 and a thousandfold that reduces the lifespan of mice by 50%”