Two weeks of restricting sleep to four hours per night reduced glucose uptake into muscle by 50%.

“sleep deprivation has a profound impact on insulin resistance I think we probably talked about this previously but if you you know some very elegant mechanistic studies where you sleep deprive people you know you let them only sleep for four hours for a week you'll reduce their glucose disposal by about half which is I mean that's a staggering amount”

“if you're not sleeping well we know you are more metabolically unwell you're going to have a higher fasting insulin you're going to have more insulin resistance”

“they did the usamin clamp and then they restricted their sleep to four hours a night for 14 consecutive days so basically they did for two weeks what we did in residency for five years and then they controlled what they were eating during that experiment so it the result I'm about to describe was not simply the result of that they ate more during that time but when they repeated the you glycemic clamps their glucose disposal had fallen by 50%”

“when you look at what I think are pretty well-documented appetitive changes in people under sleep deprivation and more importantly the inferior fuel partitioning that follows so the hyperinsulinemia the impaired glucose disposal the tendency to probably eat more crap”

“I believe the subjects were restricted to four hours of sleep a night for two weeks yeah so you know about and it's been replicated for four five and six hours for one week okay at the end of that period of time they repeated the you glycemic clamp again the gold standard for measuring insulin resistance and these patients suffered a 50% reduction in their ability to put glucose into their muscle which again would certainly rank among the five most important physiologic things to do again to put this in perspective a normal blood sugar might be a hundred milligrams per deciliter or roughly five millimolar for a normal-sized individual that represents five grams of glucose and let the siren go by here yeah it's it may actually be immigration coming to get me finally and deporting me back the United Kingdom but sorry yeah so so you've got five grams of glucose in the bloodstream which is one table teaspoon Frank diabetes would be 200 milligrams per deciliter ten to eleven millimolar two teaspoons of sugar so the amount of glucose you have in your bloodstream is trivial compared to what's in the muscles and in the liver so imagine losing the ability to put that away by 50%”

“the data for poor sleep and insulin resistance are actually quite strong i think we've talked about this many times even i i i um i i think we've spoken about this on several podcasts but you know the even short-term bouts of sleep deprivation like two weeks of four hours of sleep deprivation per night result in about a 50 reduction in glucose disposal which of course would result in hyperglycemia”

“if you you know some very elegant mechanistic studies where you sleep deprive people you know you let them only sleep for four hours for a week you'll reduce their glucose disposal by about half which is I mean that's a staggering amount of you're basically inducing profound insulin resistance in just a week of sleep deprivation”

“I think sleep is probably the most under appreciated contributor to insulin resistance and poor metabolic Health”

“even short-term bouts of sleep deprivation like 2 weeks of 4 hours of sleep deprivation per night result in about a 50% reduction in glucose disposal which of course would result in hypoglycemia”

“I don't think it can be overlooked the data for poor sleep and insulin resistance are actually quite strong”

“I think sleep is probably the most underappreciated contributor to insulin resistance and poor metabolic health.”

“insulin resistance increased by 39%”

“Losing 30 min. of sleep per day on weekdays leads to a 19% increase in obesity & 39% increase in insulin resistance.”

“if you sleep-deprive someone to 4-5 hours/night... You see a 50% reduction in their ability to dispose of glucose!”

“If you look at, you know, A1C in terms of sort of a raw shot review of blood glucose, your blood sugar, not good.”

“the cells of the body including muscle cells and fat cells um their receptors stop being as sensitive to insulin so firstly you're releasing less insulin when you're sleep deprived right but what little insulin You Do release is not instructing those cells to open up the channels to take away the monsoon of the glucose that's flowing in the channels of the body”

“if you just took a normal group of people and you did like what's called a ug glycemic insulin clamp which is a an experiment um where you you run IV glucose and IV insulin into people and and you basically run a fixed amount of insulin into somebody and then determine how much glucose you need to put in to keep their glucose level fixed that's called a ug glycemic keep glucose fixed um that's a that's the gold standard for measuring insulin sensitivity so you do that test on somebody and then for a week sleep deprive them for you know down to five or six 4 hours a night call it four four would be very dramatic uh within days you'll see like a 50% reduction in their ability to dispose of glucose with no other difference no dietary difference no exercise difference”

“I'm not sure that most people realize the profound effect that even mild sleep restriction has on our metabolic health and glucose regulation and this is extremely relevant because about onethird of people in the United States do not meet the recommendations which is 7 to 9 hours of sleep per night for sleep”

“sleep deprivation after one night, like half you're getting four hours of sleep instead of eight. You can be insulin resistant the next day.”