Paul Saladino· MD
the cortisone to the DHA sulfate ratio is is now proposed as a single best predictor of all-cause mortality and morbidity going into the future
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the cortisone to the DHA sulfate ratio is is now proposed as a single best predictor of all-cause mortality and morbidity going into the future
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it's the cortisol to DHEA ratio which just like the um the muscle mass which by the way affects the muscle mass because one of them is a category the other one uh hormone the cause of the deitration is now recognized as the best predictor of both longevity and also morbidity
so what it suggests and if you look at that study they will also argue for something less than 0.5 maybe even 0.3 is that if you have a cortisol to dhes ratio that is less than 0.3 your risk of all cause mortality cancer mortality cause specific mortality is lower than someone that has a higher ratio of those things
d-h-e-a-s-d-hydroepy androsterone sulfate which is a storage form of DHEA negatively Associated and the ratio of cortisol to DHEA was positively associated with all cause cancer and other medical cause mortality
what another good metric of Health and Longevity this cortisol to DHE ratio it's something that I spoke about on a previous podcast with Georgie dinkov and you want your cortisol to be as low as possible and your dheas to be as high as possible
basically the authors say that this is one of the best ratios for longevity and predicting low rates of cause specific mortality and all cause mortality
according to the authors a higher cortisol to dheas ratio was related to an increased risk of death by other causes in the age adjusted model the hazard ratio was 3.11
I've recently learned about some metrics on the blood work that I think can be very revealing for people and I think there's a lot of research on this cortisol to DHE ratio and it's a it's not a fasted cortisol to DHE it can be like mult times a day you can look at it but there's pretty good evidence that that ratio can tell us it's it correlates very strongly with longevity and morbidity
the cortisol to DHEA ratio is now recognized as the best predictor of both uh longevity and also morbidity. So if that if that ratio is over 0.5 in other words if it starts going in favor of cortisol you're basically looking at initially cardiovascular disease, obesity, diabetes, neurological disease and if it goes you know further higher eventually you're looking at things like uh cancer.
a recent study showed that no cancer patient had a cortisol to DHEA ratio that was below I think 1.5.
So you want a high DHES, you want a low cortisol, cheers.