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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Cortisol to DHEA-S ratio — Whalespan

Content›Video›Cortisol to DHEA-S ratio…

Cortisol to DHEA-S ratio

Paul Saladino4m · 2024-04-15

Claims Made

11

Claims Supported

9

Support Rate

82%

Support rate

9 of 11 claims supported

9 supported2 partial / not

Claims from this content

9

✓Well SupportedA cortisol to DHEA ratio below 1.5 was not observed in cancer patients, suggesting a correlation between high cortisol and cancer.✓Well SupportedStress hormones like catecholamines, epinephrine, and cortisol can increase during fasting or carbohydrate restriction to help liberate stored glycogen.✓Well SupportedImproving dietary quality is a more effective long-term strategy for weight loss than simply reducing calorie intake.✓Well SupportedLack of sleep, including conditions like sleep apnea, can lead to higher cortisol levels.Well Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Weight loss is achieved by consuming nutrient-rich, satiating foods that promote satiety and reduce hunger.

✕Not SupportedCalorie counting, fasting, and excessive physical stress elevate stress hormones, leading to long-term health problems.

◐Partially SupportedTo maintain a low cortisol to DHEA-S ratio, consume carbohydrates, prioritize nutrient-dense foods from meat and organs, ensure adequate sleep, get sun exposure, and live a less stressed life.

◐Partially SupportedPaul Saladino's cortisol level is 12.5 and DHEA-S level is 142, resulting in a cortisol to DHEA-S ratio of 0.084.

◐Partially SupportedTo promote longevity, one should sleep, get sun, eat meat, and not fear carbohydrates, while avoiding excessive cold plunge and sauna stress.