Andrew Huberman· PhD
NAD levels decline with age.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
NAD levels decline with age.
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now as we age these levels go down
As we age, tissues make less and degrade more NAD, so we have less fuel for Sirtuins… https://t.co/U0m1BZolV0
The problem is as we get older we make less NAD and we also destroy it more for reasons that we don't fully understand, but it leads to a decline in our ability to fight off aging and the diseases that it causes.
nad levels and at the cellular level or and even mitochondrial level are decreased with aging right
One word of caution I think there is, we do not know why these levels decrease. They could decrease because we have decreased production of NAD, but it could also decrease because we have accelerated destruction of NAD, which means, if it’s accelerated destruction, bringing more into it is sort of like pouring more NAD in a leaky sink.