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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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What is post-finasteride syndrome? | Peter Attia & Mohit Khera — Whalespan

Content›Video›What is post-finasteride syn…

What is post-finasteride syndrome? | Peter Attia & Mohit Khera

Peter Attia8m · 2024-11-19

Claims Made

13

Claims Supported

11

Support Rate

85%

Support rate

11 of 13 claims supported

11 supported2 partial / not

Claims from this content

12

✓Well SupportedPost-finasteride syndrome symptoms can be permanent in some individuals after drug discontinuation.✓Well SupportedThere is an increased risk of suicide in men taking finasteride, irrespective of belief in post-finasteride syndrome.◐Partially SupportedMen taking finasteride for hair loss at age 30 may recognize persistent side effects as abnormal, unlike older men who might attribute them to normal aging.◐Partially SupportedFinasteride blocking progesterone conversion to allopregnanolone is a problem because allopregnanolone is implicated in depression, anxiety, and cognition.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Men who committed suicide while taking finasteride had no significant prior history of mental illness.

◐Partially SupportedAny drug associated with increased suicidal rates warrants close examination.

◐Partially SupportedRandomized assignment trials or post-hoc analyses are needed to investigate the link between finasteride and suicide risk.

◐Partially SupportedFinasteride and dutasteride carry an increased risk of suicidal ideation, according to warnings from Canada, France, and the UK.

◐Partially SupportedThe American Urologic Association acknowledges that patients can experience prolonged side effects from finasteride.

◐Partially SupportedLingering sexual side effects of finasteride and dutasteride after drug cessation may be explained by epigenetic mechanisms like silencing of the 5-AR gene through DNA methylation.

◐Partially SupportedPatients taking finasteride or dutasteride have reported post-finasteride syndrome symptoms including sexual dysfunction, depression, and anxiety.

◐Partially SupportedBlocking the conversion of progesterone into allopregnanolone is a significant problem for depression, anxiety, and cognitive function.