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Medical tests for dementia and their relationship to clinical symptoms — Whalespan

Content›Video›Medical tests for dementia a…

Medical tests for dementia and their relationship to clinical symptoms

Peter Attia12m · 2021-06-10

Claims Made

16

Claims Supported

8

Support Rate

50%

Support rate

8 of 16 claims supported

8 supported8 partial / not

Claims from this content

15

✓Well SupportedAmyloid PET scans have about 97% accuracy in diagnosing Alzheimer's disease in living people compared to post-mortem analysis.✓Well SupportedAlzheimer's disease has a pre-clinical, pre-symptomatic phase.◐Partially SupportedTracking hippocampal volume changes over time can provide insight into Alzheimer's progression.◐Partially SupportedTau pathology has a specific spread pattern that correlates with Alzheimer's symptoms and may determine symptom severity.◐Partially Supported

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Peter Attia on Zone 2 Cardio

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Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Shrinking in the hippocampus, particularly disproportionately to other brain areas, can be a biomarker of Alzheimer's disease.

◐Partially SupportedAmyloid buildup in the brain can begin 10-20 years before the onset of cognitive symptoms like forgetfulness.

◐Partially SupportedPrior to 2011, the FDA defined Alzheimer's solely as dementia, preventing research on prodromal patients.

◐Partially SupportedAmyloid imaging in 2011 allowed for the redefinition of Alzheimer's to include preclinical stages with amyloid buildup before symptom onset.

◐Partially SupportedCoronary calcification, like amyloid buildup, can exist without clinically manifesting as cardiovascular disease until a later event.

◐Partially SupportedChronically elevated cortisol levels are associated with smaller hippocampi.

◐Partially SupportedThe diagnosis of Alzheimer's disease requires the clinical story, and amyloid is neither necessary nor sufficient for dementia.

◐Partially SupportedAmyloid plaques and tau tangles are required for an Alzheimer's disease diagnosis, technically made post-mortem.

◐Partially SupportedAmyloid PET scans use an antibody to amyloid as a tracer, unlike FDG PET scans which use radio-labeled glucose.

◐Partially SupportedMRI evaluations for dementia typically involve ruling out or quantifying vascular disease, such as small strokes that can accumulate with aging due to factors like high blood pressure, high cholesterol, smoking, diabetes, or normal aging.

◐Partially SupportedAccumulation of small strokes can become symptomatic if they coalesce or extend into critical cortical areas.