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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Is your nocturnal urinary frequency normal? | Peter Attia & Ted Schaeffer — Whalespan

Content›Video›Is your nocturnal urinary fr…

Is your nocturnal urinary frequency normal? | Peter Attia & Ted Schaeffer

Peter Attia14m · 2023-10-07

Claims Made

25

Claims Supported

22

Support Rate

88%

Support rate

22 of 25 claims supported

22 supported3 partial / not

Claims from this content

20

✓Well SupportedAnti-diuretic hormone levels decrease with age, leading to increased urine production during waking hours.✓Well SupportedAlpha-blockers are a frontline treatment for lower urinary tract symptoms by relaxing prostate and seminal vesicle smooth muscles.✓Well SupportedSleep apnea can lead to symptomatic nighttime urine production and frequency due to dysregulation of anti-diuretic hormones.✓Well SupportedConsuming no more than 5-8 ounces of fluid between 10 hours after waking and bedtime, and sipping it slowly, can reduce nighttime awakenings to urinate.Partially Supported

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Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Urinating once per night for a 50-year-old man is within normal variability and may relate to fluid intake timing.

◐Partially SupportedAlcohol consumption before bed inhibits the release of anti-diuretic hormone, leading to increased nighttime urination.

◐Partially SupportedWearing knee-high compression stockings and modifying fluid intake timing can reduce nighttime urinary frequency by approximately one episode per night.

◐Partially SupportedA voiding diary tracks fluid intake and urinary output to help individuals monitor consumption.

◐Partially SupportedPeripheral edema in aging individuals can contribute to nighttime urinary frequency by causing fluid to shift during sleep.

◐Partially SupportedThe resiliency of capillaries and the vascular system decreases with age, leading to increased capillary leak and fluid accumulation.

◐Partially SupportedA voiding diary can be used for persistent or unusual urinary symptoms, especially if hormonal deficiencies are suspected.

◐Partially SupportedRegulating fluid intake timing and volume are first steps in managing lower urinary symptoms.

✕Not SupportedHyponatremia is a theoretical contraindication for desmopressin use due to its potential to increase plasma volume and dilute sodium.

◐Partially SupportedModern alpha-blockers are selective for relaxing prostate smooth muscles without causing significant drops in blood pressure.

◐Partially SupportedThird-generation alpha-blockers like alusin and sopin are effective at relaxing the prostate with fewer sexual side effects.

◐Partially SupportedAlpha-blockers can cause profound hypotension as a side effect.

◐Partially SupportedIncreasing fluid intake leads to increased urinary output.

◐Partially SupportedCaffeine acts as a diuretic and can increase urine production within two to four hours of consumption.

◐Partially SupportedLow-dose desmopressin (typically 2mg before bed) can be used pharmacologically to manage nighttime urinary frequency in men without an enlarged prostate.

◐Partially SupportedSmooth muscle in the prostate acts as a pump to aid in seminal fluid emission during ejaculation.