Audit a URL →

Sign in Sign up free

Loading…

Weekly · Sunday Morning

Five longevity claims.
Worth your time.
Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

5 audits·1 verdict change·0 affiliate links·Every Sunday

Joining 1,247 readers — founders, MDs, and longevity-obsessed people who fact-check their own health decisions.

Browse

Decisions Claims Content Creators

Product

Audit a URL Sunday roundup API (soon)Pricing

About

FAQ Methodology Editorial Standards Corrections Press & brand RSS feed

Legal

Terms of Service Privacy Policy DMCA

Finally, something serious in this space.
Because we actually read the papers.

© 2026 Whalespan. Independent, evidence-graded longevity.

"Hacking Your Genes" at SF Nerd Nite — Whalespan

Content›Video›"Hacking Your Genes" at SF N…

"Hacking Your Genes" at SF Nerd Nite

Rhonda Patrick17m · 2014-02-18

Claims Made

30

Claims Supported

29

Support Rate

97%

Support rate

29 of 30 claims supported

29 supported1 partial / not

Claims from this content

26

✓Well SupportedVitamin D deficiency accelerates the aging process.✓Well SupportedExercising four hours per week can increase neurogenesis, including growth of new brain cells and the hippocampus.✓Well SupportedFactors such as sunscreen use, dark skin color, high body fat, and old age can impair vitamin D production from sun exposure.◐Partially SupportedMice genetically engineered for neurodegenerative disease showed improved learning and memory and increased long-term potentiation when placed in an enriched environment, and these benefits were passed on to their offspring.Partially Supported

More from Rhonda Patrick

Rhonda Patrick on Sauna Use

Discussion

Native comments, Twitter mentions, and Reddit threads about this content — surfaced together so the conversation isn't fragmented across platforms.

M

Share your read of this content…

Posting publicly as you · linked to your social profiles

Sort by:

AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Calorically restricted monkeys show decreased expression of genes involved in inflammation and stress, and increased expression of neurotrophic factors.

◐Partially SupportedMale mice fed a high-fat diet became obese and diabetic, and their female offspring, even when fed a normal diet, also developed diabetes in adulthood.

◐Partially SupportedFeeding female mice with the Agouti gene a diet high in B vitamins before pregnancy resulted in offspring with silenced Agouti gene expression, preventing obesity, cancer, and type 2 diabetes predispositions.

◐Partially SupportedDiet and lifestyle changes can alter gene expression, overriding genetic predispositions.

◐Partially SupportedFactors that increase neurogenesis include exercise, dark chocolate, tea, blueberries, red wine, sex, and cannabinoids.

◐Partially SupportedFemale rat pups not licked within the first 10 days of life are more promiscuous due to increased estrogen receptors in the hypothalamus.

◐Partially SupportedEpigenetics can be influenced by diet from previous generations, suggesting potential for inherited dietary impacts.

◐Partially SupportedEpigenetic marks are regulated by environmental factors including diet, time of day, food intake amount, exercise, and stress.

◐Partially SupportedEpigenetic factors can activate or silence genes, regulating gene expression.

◐Partially SupportedEpigenetic marks regulated by the environment can be passed on to future generations.

◐Partially SupportedObesity increases the risk of diseases such as diabetes and cardiovascular disease.

◐Partially SupportedThe mechanism by which obesity increases cancer risk is not well understood.

◐Partially SupportedFruits and vegetables are the primary source of essential micronutrients for biochemical pathway function.

◐Partially SupportedMaternal licking in rat pups leads to reduced nervousness and better stress coping abilities in adulthood due to serotonin release in the hippocampus and changes in gene expression.

◐Partially SupportedThe typical American diet is obesogenic, consisting primarily of processed foods with minimal fruits and vegetables.

◐Partially SupportedCaloric restriction (30% less food) in monkeys leads to a biologically younger state, reducing the likelihood of diabetes, cancer, and neurodegenerative disease.

◐Partially SupportedA three-month lifestyle intervention including diet, supplements, exercise, and meditation changed gene expression in men with low-risk prostate cancer.

◐Partially SupportedMales who grew up during famine years in northern Sweden between the ages of 9 and 12 had healthier children and grandchildren, with grandchildren being one-fourth less likely to get diabetes and cardiovascular disease and living an average of 3.2 years longer.

◐Partially SupportedMaternal licking in rat pups increases glucocorticoid receptors and reduces cortisol production, leading to calmer behavior and better stress coping.

◐Partially SupportedCaloric restriction in monkeys leads to a decrease in gene expression related to inflammation and stress, and an increase in gene expression related to neurotrophic factors.

◐Partially SupportedOffspring of mice exposed to enriched environments show benefits in learning and memory tests and increased long-term potentiation.

◐Partially SupportedLifestyle changes like diet and exercise may provide similar benefits to pharmaceutical drugs targeting tumor suppressor genes, with positive side effects.