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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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What are the best lab tests to request from your PCP? (AMA #1) — Whalespan

Content›Video›What are the best lab tests …

What are the best lab tests to request from your PCP? (AMA #1)

Peter Attia13m · 2020-01-18

Claims Made

23

Claims Supported

17

Support Rate

74%

Support rate

17 of 23 claims supported

17 supported6 partial / not

Claims from this content

18

✓Well SupportedOptimal two-hour glucose after a 75g glucose challenge should be below 100 mg/dL and insulin ideally below 20 or approximately twice the one-hour insulin level.✓Well SupportedEstimating VLDL cholesterol by subtracting LDL cholesterol from non-HDL cholesterol is a method that does not always agree with other estimation methods.◐Partially SupportedLipoprotein(a) [LP(a)] is an LDL-like particle containing ApoB and Apo(a) moieties, with ApoB being a marker of atherogenic lipoproteins.✓Well SupportedLp(a) is a relevant biomarker for cardiovascular health.Well Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Elevated ALT may suggest non-alcoholic fatty liver disease (NAFLD).

✓Well SupportedPostprandial hyperinsulinemia is an early metabolic indicator of insulin resistance and related health issues.

✓Well SupportedUsing normal glucose sources like rice or potatoes for an OGTT may provide more accurate results than liquid glucose for some individuals.

◐Partially SupportedMeasuring insulin is essential for a complete glucose tolerance test and cannot be done at home.

✕Not SupportedElevated ALT levels above 48 U/L are alarming.

✓Well SupportedHigh-sensitivity CRP, homocysteine, oxidized LDL, myeloperoxidase, lipoprotein phospholipase A2, PTH D3, ApoB, and ApoA1 directly indicate the state of the vasculature.

◐Partially SupportedLP Little A and ApoB are essential lab tests that everyone should have checked at least once.

◐Partially SupportedLP Little A is considered the single most important lipoprotein, followed by LDL P and small LDL particles.

◐Partially SupportedApoB levels are influenced by cholesterol synthesis, reabsorption, triglyceride levels, and the efficiency of the LDL receptor.

✕Not SupportedTotal cholesterol has zero utility in clinical practice, except for diagnosing familial hypercholesterolemia to qualify for PCSK9 inhibitors.

?Limited ResearchIncreasing HDL cholesterol pharmacologically or dietarily does not appear to confer benefit, and HDL C may rise as a consequence of beneficial dietary changes.

◐Partially SupportedApoB genotyping is important for assessing cardiovascular risk and predicting Alzheimer's disease.

◐Partially SupportedEstradiol levels in men have shown an upward drift in reference ranges over the past eight years.

◐Partially SupportedVLDL cholesterol can be estimated by subtracting LDL cholesterol from non-HDL cholesterol and should ideally be less than 15 mg/dL.