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Weekly · Sunday Morning

Five longevity claims.
Worth your time.
Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Build Your Autonomous Self - Ep 4 — Whalespan

Content›Video›Build Your Autonomous Self -…

Build Your Autonomous Self - Ep 4

Bryan Johnson40m · 2023-07-02

Claims Made

60

Claims Supported

40

Support Rate

67%

Support rate

40 of 60 claims supported

40 supported20 partial / not

Claims from this content

39

◐Partially SupportedBryan Johnson's biological age is 45, with specific organ ages ranging from 18 to 64.✓Well SupportedCaloric restriction can lower testosterone, potentially necessitating supplementation.✓Well SupportedBryan Johnson is implementing an eye protocol involving drops and a vibrating device to address cataracts and dry eye syndrome.✓Well SupportedBryan Johnson completed a full-body Intense Pulsed Light (IPL) therapy.✓Well Supported

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Bryan Johnson's Blueprint Rapamycin Protocol

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Testosterone levels of 800 ng/dL or higher are within the normal distribution for a significant portion of the population.

✓Well SupportedEpigenetic reprogramming is a step towards achieving longevity escape velocity.

✓Well SupportedKeeping the bedroom as dark as possible using blackout curtains and an eye mask can improve sleep.

◐Partially SupportedStopping liquid intake around noon can help avoid nighttime urination.

✕Not SupportedPornography is not good for the brain.

◐Partially SupportedBreathwork is more helpful than meditation for methodical practice.

◐Partially SupportedThe speaker uses a laser cap with 312 diodes, a topical solution, and monthly PRF with dutasteride and acell for hair health.

◐Partially SupportedEating earlier and lighter optimizes sleep.

◐Partially SupportedHGH therapy led to a decrease in IGF-1 by approximately 15%.

◐Partially SupportedThe speaker is beginning MSC therapy in October.

◐Partially SupportedAutologous fat transplants were used to restore facial volume.

◐Partially SupportedLaser therapy is effective for treating acne scars and wrinkles.

◐Partially SupportedGlycine is taken with NAC as part of a supplement stack.

✕Not SupportedBryan Johnson paused HGH therapy due to side effects.

◐Partially SupportedMinor deviations in daily habits can negatively impact sleep quality.

✕Not SupportedThe HGH protocol caused intracranial pressure, headaches, and reduced sleep quality.

◐Partially SupportedConsuming a quarter cup of berries daily, along with pomegranate juice and a nutty pudding, is part of his fruit intake.

◐Partially SupportedVegetables contain anti-nutrients, and the carnivore diet may be better supported by data.

◐Partially SupportedThe speaker takes metformin for polyp avoidance in the small intestinal tract and for blood glucose management.

◐Partially SupportedGrounding sheets are used for glutathione production, with some evidence supporting this effect.

◐Partially SupportedVision of 20/15 and 20/20 is considered good, with potential for further improvement through eye procedures.

◐Partially SupportedThe speaker is undergoing water quality tests to establish a baseline.

◐Partially SupportedAiming for neutral urine color ensures adequate water intake.

◐Partially SupportedThe speaker has used Sculptra for facial revolumization.

◐Partially SupportedBryan Johnson avoids heavy weights in training to prevent injury, prioritizing reps over weight.

◐Partially SupportedThe speaker consumes no sugar in his diet.

◐Partially SupportedVitamin D is taken at a dose of 2000 IU daily.

◐Partially SupportedGood posture may reduce white matter hyperintensities.

◐Partially SupportedThe speaker's Blueprint protocol is based on evidence but acknowledges gaps and may omit other beneficial practices.

◐Partially SupportedInterventions to eliminate cataracts and manage dry eye syndrome are being explored.

◐Partially SupportedCaloric restriction has been maintained while preserving muscle mass.

✕Not SupportedCaloric restriction led to a loss of facial fat volume.

◐Partially SupportedFinding consistently good quality 100% dark chocolate has been difficult.

◐Partially SupportedThe speaker is trialing microbiome interventions for IBS and will share them publicly if effective.

◐Partially SupportedLooking at distant objects (100 yards or more) throughout the day can train the eye on different focal points.