Andrew Huberman· PhD
In fact, we can measure it in such a way that we can predict when somebody is going to die based on the changes in those chemicals.
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In fact, we can measure it in such a way that we can predict when somebody is going to die based on the changes in those chemicals.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
These clocks are acknowledged as highly accurate molecular correlates of chronological age in humans and other vertebrates.
if I took your skin cell or your blood, and I measured the DNA methylation pattern across the genome, across that six feet in one cell or in thousands of cells, which is how we do it, I can then plug that into a program, and it'll spit out your actual biological age. Not your birthday candles, which is based on how many times the earth has gone around the sun. That's irrelevant. It's how old you really are which can predict also when you're going to die.
Not your birthday candles, which is based on how many times the earth has gone around the sun. That's irrelevant. It's how old you really are which can predict also when you're going to die.
Steve measures the methylation on the DNA. It's a chemical called a methyl that the cells add to the DNA and it sticks there, it doesn't wash away, and it makes sure cells have their identity and play the right genes for the rest of your life.
he is able to estimate not just how old you are but predict when you're gonna die with high accuracy.
this whole question about this methyl o'clock is something that it's an intense area of interest in the biological community it's evolving a lot there's a bunch of labs that are working on this and it's going to be very interesting next five years to see where this drops out
horvat and morgan levine and some other people around the world have looked at methylation sites and tried to correlate them to chronological age okay and it's a big process but more important and more the most important thing is to distinct between biological age and chronological age and there's a huge body of work that really showed that methylation clogs and they're in development there's newer and better that methylation clocks are good they're really good clocks of biological age in particular when you see if they predict mortality for example but also prediction of a lot of diseases
and Steve Horvat has done beautiful work I mean it's really pioneering work identifying and all this and uh Morgan Lavine and others have have gone on you know Dan Bellski I think with Denedin Pace uh which is another epigenetic clock that measures the pace of aging.
So he's shown that from multiple tissues from humans, blood cells, and also different biopsies from different samples, that there's a pattern of methylation that appears to be specific to age. And it's so precise that researchers can look at this methylation pattern from, for example, lymphocytes taken from a person and they can identify the person's age plus or minus four years with 96% accuracy.