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Rapamycin extends mouse lifespan 9–14%
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The Phospholipid Brain-DHA Advantage — Whalespan

Content›Video›The Phospholipid Brain-DHA A…

The Phospholipid Brain-DHA Advantage

Rhonda Patrick11m · 2014-09-29

Claims Made

30

Claims Supported

29

Support Rate

97%

Support rate

29 of 30 claims supported

29 supported1 partial / not

Claims from this content

24

✓Well SupportedThe Omega-3 Index, measuring omega-3 levels in red blood cells, is a long-term biomarker of omega-3 status, unlike plasma phospholipid levels which reflect recent intake.✓Well SupportedOmega-3s from krill oil in phospholipid form yield higher plasma EPA and DHA concentrations than triglyceride or ethyl ester forms at identical doses.✓Well SupportedMice engineered to lack the MFSD2A transporter had 60% less DHA in their brains compared to control mice, while DHA levels in the heart and liver remained unchanged.✓Well SupportedWhen choosing fish oil, prioritize triglyceride form over ethyl ester form, low oxidation status, and high EPA & DHA concentration.Well Supported

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A. Volkovreader

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Omega-3 supplements appear to affect telomere length in a dose-response manner.

✓Well SupportedThe speaker takes extra EPA and krill oil for DHA in phosphatidylcholine form for brain health.

✓Well SupportedRhonda Patrick takes Nordic Naturals fish oil for EPA and krill oil for DHA phosphatidylcholine.

✓Well SupportedOmega-3 fatty acids EPA and DHA are crucial for combating inflammation and cell structure, particularly in the brain.

✓Well SupportedOmega-3 fatty acids, particularly DHA, reduce triglycerides.

◐Partially SupportedSupplementing with fish oil reduces all-cause mortality, according to RCT meta-analyses.

◐Partially SupportedFish oil supplementation for 5 years prevented hippocampal brain atrophy and maintained function in the elderly.

◐Partially SupportedAstaxanthin, found in krill oil, is a potent antioxidant that sequesters singlet oxygen and protects against peroxy radicals, preventing damage to DNA, lipids, and proteins.

◐Partially SupportedOmega-3 fatty acids in triglyceride form are more bioavailable than ethyl ester form but less bioavailable than phospholipid form.

◐Partially SupportedOmega-3 fatty acids are critical for cell membrane fluidity, impacting neurotransmitter function like norepinephrine for focus and attention.

◐Partially SupportedDHA lysa phosphatidylcholine is the preferred source of DHA for the brain, transported across the blood-brain barrier by the transporter MFSD2A.

◐Partially SupportedOmega-3 fatty acids are a top dietary factor influencing early mortality.

◐Partially SupportedSupplementing with astaxanthin has been shown in clinical trials to lower inflammation, decrease DNA damage, and increase HDL.

◐Partially SupportedPhospholipids are better absorbed than triglycerides because gastric lipase cannot break down phospholipids.

◐Partially SupportedKrill oil contains a unique antioxidant not found in fish oil.

◐Partially SupportedAstaxanthin can accumulate in cell membranes, protecting DHA and other polyunsaturated fatty acids prone to oxidation.

◐Partially SupportedKrill oil contains phosphatidyl serine and phosphatidyl ethanolamine, which may contribute to neurodegenerative diseases.

◐Partially SupportedDHA comprises 10-20% of total lipids or about 60% by dry weight in the brain.

◐Partially SupportedOmega-3 fatty acids lower inflammation, which causes tissue damage and plays a role in cancer.

◐Partially SupportedMolecular distillation of fish oil converts omega-3s from triglyceride to ethyl ester form, which is less bioavailable.