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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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The Underlying Mechanisms of Depression — Whalespan

Content›Video›The Underlying Mechanisms of…

The Underlying Mechanisms of Depression

Rhonda Patrick9m · 2017-02-06

Claims Made

14

Claims Supported

14

Support Rate

100%

Support rate

14 of 14 claims supported

14 supported0 partial / not

Claims from this content

11

✓Well SupportedSupplementing with 1,000 milligrams of EPA daily can allow individuals requiring prescription antidepressants to use lower doses of those medications.✓Well SupportedNeurotoxic metabolites of kynurenine are likely primary contributors to depression genesis in the context of inflammation.✓Well SupportedEndurance exercise can beneficially alter kynurenine metabolism by increasing muscle tissue activity of kynurenine amino transferase.✓Well SupportedPro-inflammatory molecules and cytokines can cross the blood-brain barrier and disrupt neurotransmitter production and release, contributing to depressive symptoms.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Inflammation plays a significant role in major depressive disorder, and high C-reactive protein levels are seen in some non-responders to SSRIs.

✓Well SupportedOmega-3 fatty acid EPA prevented the increase in depressive symptoms when co-administered with pro-inflammatory cytokines.

✓Well SupportedMany forms of major depression are related to excessive inflammation.

✓Well SupportedInjecting pro-inflammatory cytokines into healthy individuals can induce depressive symptoms.

◐Partially SupportedLifestyle interventions for depression may include programs to reduce visceral fat and meet dietary requirements for reducing inflammation.

◐Partially SupportedMitigating inflammation may become a primary objective in depression management, potentially including monitoring inflammatory biomarkers for therapeutic success.

◐Partially SupportedObesity, poor nutrition, gut health, sedentary lifestyle, poor sleep, and social stress can lead to an exaggerated and prolonged inflammatory response.