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Rapamycin extends mouse lifespan 9–14%
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The history of steroids | Peter Attia & Derek MPMD — Whalespan

Content›Video›The history of steroids | Pe…

The history of steroids | Peter Attia & Derek MPMD

Peter Attia11m · 2023-11-14

Claims Made

30

Claims Supported

18

Support Rate

60%

Support rate

18 of 30 claims supported

18 supported12 partial / not

Claims from this content

27

◐Partially SupportedNandrolone (Deca) may allow bodybuilder-level results without hair loss due to its unique metabolism.◐Partially SupportedSelective Androgen Receptor Modulators (SARMs) are designed to be more anabolic relative to androgenic than compounds like Primobolan and Anavar.◐Partially SupportedTrenbolone is a steroidal SARM with significant anabolic and progestogenic activity.◐Partially SupportedSARMs are proportionally more successful than anabolic steroids in achieving selectivity but have lower anabolic activity.Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

LGD-4033 (Ligandrol) is a potent SARM, previously known as VK5211, and was in a Phase II trial for hip fracture patients.

◐Partially SupportedOstarine (Enobosarm) was a SARM that did not receive FDA approval and did not meet its target endpoints.

◐Partially SupportedCompounds like Trenbolone that significantly interact with the progesterone receptor are more suppressive, leading to negative feedback through AR, ER, and PR pathways.

◐Partially SupportedTestosterone was first synthesized around the 1930s or 1940s and has been in use for nearly 100 years.

◐Partially SupportedTrenbolone can cause severe side effects including night sweats and coughing fits.

◐Partially SupportedSARMs become less selective as dosage increases.

◐Partially SupportedSARMs are banned and highly detectable in natural bodybuilding competitions because they are not supposed to be present in the body.

◐Partially SupportedWomen may use Ostarine to bridge the gap between non-use and steroid use without virilization for bodybuilding physiques.

◐Partially SupportedThe ideal anabolic agent would segregate anabolic from androgenic activity, aiming for maximum anabolic outcomes with minimal androgenic outcomes.

◐Partially SupportedPrimobolan is a synthetic anabolic steroid that converts very little into estrogen.

◐Partially SupportedThe development of anabolic agents included compounds like Dianabol, Boldenone, and DHT derivatives such as Oxandrolone and Primobolan.

◐Partially SupportedProviron and Mystone are potent drugs for binding SHBG.

◐Partially SupportedPrimobolan is often the drug of choice for bodybuilders seeking the most anabolic effect.

◐Partially SupportedPrimobolan and Anavar are skewed towards the furthest direction of anabolic relative to androgenic effects.

◐Partially SupportedSARMs have a more extreme anabolic to androgenic ratio than Primobolan and Anavar.

◐Partially SupportedSelective estrogen receptor modulators (SERMs) interact with estrogen receptors in a tissue-specific way.

◐Partially SupportedDianabol's water retention can be beneficial for cushioning joints during heavy lifting.

◐Partially SupportedDHT derivatives can be manipulated to be more anabolic and tissue-selective to treat muscle wasting without extreme virilization.

◐Partially SupportedTestosterone exhibits roughly equal anabolic and androgenic activity in muscle, based on rodent studies.

◐Partially SupportedDianabol is a testosterone derivative that Arnold Schwarzenegger called 'The Breakfast of Champions'.

◐Partially SupportedBoldenone is a testosterone derivative that was previously prescribed to horses and may not have had human use.

◐Partially SupportedHalotestin is a testosterone derivative, and some historical protocols for its use were nonsensical.

◐Partially SupportedOn a scale of 1 to 10, where 5 is testosterone, DHT derivatives would be closer to 1 (more androgenic than anabolic), and Primobolan would be closest to 10 (most anabolic).