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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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Do mTOR, IGF 1 and dairy accelerate aging? — Whalespan

Content›Video›Do mTOR, IGF 1 and dairy acc…

Do mTOR, IGF 1 and dairy accelerate aging?

Paul Saladino10m · 2023-02-17

Claims Made

23

Claims Supported

18

Support Rate

78%

Support rate

18 of 23 claims supported

18 supported5 partial / not

Claims from this content

19

✓Well SupportedObservational evidence does not support the hypothesis that dairy fat contributes to obesity or cardiometabolic risk; higher intake is associated with lower obesity risk.◐Partially SupportedIntake of milk and dairy products was associated with reduced risk of childhood obesity.◐Partially SupportedCertain indigenous populations are free from chronic diseases like obesity, diabetes, cardiovascular disease, autoimmunity, cancer, depression, and dementia.◐Partially SupportedValter Longo's study suggests individuals under 65 who ate less protein had better outcomes, while those over 65 had worse outcomes.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Valter's study found that individuals over 65 had lower mortality with higher protein intake, while those under 65 had the opposite association.

✓Well SupportedThere is likely no benefit to a low-protein diet in older adults, excluding those with renal insufficiency.

◐Partially SupportedConsistent over-activation of IGF-1 primarily comes from insulin resistance, not from foods signaling abundance like meat, organs, and dairy.

✕Not SupportedPolyunsaturated fatty acids, particularly those found in margarine, are detrimental to health.

◐Partially SupportedMargarine intake is associated with a higher rate of cardiovascular disease.

◐Partially SupportedAvoiding insulin resistance involves not over-activating cortisol, maintaining a healthy gut, and avoiding polyunsaturated fatty acids, especially from seed oils.

◐Partially SupportedThe Maasai people consume significant amounts of dairy and blood and show low incidence of chronic disease.

✕Not SupportedThe widespread use of rapamycin may lead to an increase in overall infections, including tuberculosis and pulmonary infections.

◐Partially SupportedMany Westerners consume meat with added sugars, high fructose corn syrup, seed oils, and refined flours, often in processed foods.

◐Partially SupportedMargarine consumption is associated with increased cardiovascular disease risk, outweighing confounding factors like smoking and drinking.

◐Partially SupportedAnthropology should be taught in medical schools to highlight the existence of free-living human populations free from chronic diseases.

◐Partially SupportedAdequate protein intake, specifically the amino acid leucine, and postprandial insulin signaling are important for immune system function.

✕Not SupportedPolyunsaturated fatty acids (PUFAs) are generally not favored.

◐Partially SupportedEpidemiological studies show a correlation between margarine intake and increased coronary heart disease risk.

◐Partially SupportedThere are immunological trade-offs associated with mTOR deficiency, including an increased risk of infections, particularly mycobacterial infections.