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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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Jim Kean Talks Biomarkers, Building a Spectator Sport — Whalespan

Content›Video›Jim Kean Talks Biomarkers, B…

Jim Kean Talks Biomarkers, Building a Spectator Sport

Rhonda Patrick34m · 2015-07-01

Claims Made

55

Claims Supported

52

Support Rate

95%

Support rate

52 of 55 claims supported

52 supported3 partial / not

Claims from this content

32

✓Well SupportedExercise increases tryptophan's entry into the brain by alleviating competition with branched-chain amino acids, thereby increasing serotonin production.✓Well SupportedAthletes tend to have lower magnesium intake compared to the general population.✓Well SupportedMost serotonin is produced in the gut, does not cross the blood-brain barrier, and plays a role in gut inflammation, vasoconstriction, and clotting.◐Partially SupportedIn true overtraining, anabolic hormone recovery, such as testosterone, can be significantly delayed and difficult.Partially Supported

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◐

Inflammation from insulin resistance can lead to neurodegenerative diseases like Alzheimer's by facilitating immune reactions and amyloid beta plaque aggregation.

◐Partially SupportedConsuming simple sugars or carbohydrates can impair cognitive function.

◐Partially SupportedJim Kean no longer prioritizes LDL cholesterol levels if his ApoA/ApoB ratio is good and inflammation markers are in order.

✓Well SupportedConsumers should regularly quantify their health biomarkers to understand trends rather than relying on single data points.

◐Partially SupportedDuring an inflamed state, the body increases VLDL production because it binds to endotoxin, a beneficial response to mitigate damage from toxins.

◐Partially SupportedInsulin-like receptor 1 (IRS1) may be a diagnostic biomarker for Alzheimer's disease 10 years in advance with 100% accuracy.

◐Partially SupportedQuinolinic acid, derived from kynurenine, crosses the blood-brain barrier, causes neuroinflammation, and is associated with depression.

◐Partially SupportedAccumulating heavy metals from pavement and cleaning products increases biological load and is detrimental.

◐Partially SupportedIndividuals with insulin resistance and type 2 diabetes are more likely to develop Alzheimer's disease, sometimes called 'type 3 diabetes'.

◐Partially SupportedMaintaining lean muscle mass and insulin sensitivity are the two most important factors for healthspan.

◐Partially SupportedManaging one's biology as a system involves considering the cumulative influence of lifestyle inputs like diet, and reducing the biological load of toxins and heavy metals.

◐Partially SupportedSupplementation for athletes during regular training should focus on supporting recovery.

◐Partially SupportedThere is a U-shaped curve for Vitamin D levels and mortality, meaning both too much and too little Vitamin D can be detrimental.

◐Partially SupportedLDL cholesterol is necessary for repairing cellular damage and building new cells.

◐Partially SupportedJim Kean found his optimal Vitamin D level to be 50, as higher or lower levels increased his inflammation.

◐Partially SupportedThe average athlete can tolerate approximately 15% of the workload as maximum physical load before experiencing a rapid decline, with exceptional athletes tolerating up to 16-18%.

◐Partially SupportedStress and inflammation can lead to increased VLDL production as an adaptive response.

◐Partially SupportedInflammation from gut barrier breakdown leads to smaller, endotoxin-bound LDL particles that initiate foam cell formation in blood vessels.

◐Partially SupportedRe-testing cholesterol every 3-4 months provides a better long-term view than a single measurement for guiding statin prescription.

◐Partially SupportedStatins may increase lifespan by approximately 5 years for individuals unwilling to make lifestyle changes.

◐Partially SupportedLipoprotein particle testing has become more accessible to the average person.

◐Partially SupportedMuscle exercise converts kynurenine into a metabolic byproduct that cannot be converted into quinolinic acid, thus preventing neuroinflammation.

◐Partially SupportedOvertraining beyond the 99th percentile leads to a significant negative impact on performance.

◐Partially SupportedRegularly tracking biomarkers provides a trend picture rather than a single data point.

◐Partially SupportedTracking and measuring biology through the Quantified Self movement can lead to improvements in mental performance, physical performance, and healthspan.

◐Partially SupportedSpectre bio harnesses can measure respiration and heart rate, and indicate if athletes are 'redlining' or experiencing high lactic acid levels.

◐Partially SupportedMeasuring biomarkers benefits athletes by assessing health and providing physiological insights.

◐Partially SupportedReproductive hormones are significant biomarkers for detecting overtraining in athletes.