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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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What is Neu5gc and is it harmful? — Whalespan

Content›Video›What is Neu5gc and is it har…

What is Neu5gc and is it harmful?

Paul Saladino9m · 2022-03-05

Claims Made

23

Claims Supported

9

Support Rate

39%

Support rate

9 of 23 claims supported

9 supported14 partial / not

Claims from this content

16

✓Well SupportedAn animal-based diet including organs is central to thriving for most people.◐Partially SupportedLDL is not problematic unless an individual is insulin resistant and is involved in arterial healing.◐Partially SupportedHumans lost the ability to synthesize N-glycolylneuraminic acid (Neu5Gc) approximately two to three million years ago due to a mutation in the enzyme CMAH.◐Partially SupportedA study on kidney transplant recipients showed no association between anti-Neu5gc antibody levels and colon cancer incidence.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

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◐

There are no human studies showing N-glycolylneuraminic acid (Neu5Gc) or antibodies against it are problematic.

◐Partially SupportedMuskellids that prey on small mammals rich in Neu5Gc do not exhibit massive cancers, suggesting Neu5Gc is not inherently harmful.

◐Partially SupportedHumans possess Neu5ac, a sialic acid that differs from Neu5gc by a single oxygen atom.

✕Not SupportedThere is not good evidence in humans that Neu5gc is harmful, similar to the situation with TMAO where animal or observational studies differ from human findings.

◐Partially SupportedNeu5Gc, a sialic acid present in meat and organs, is unlikely to be harmful to humans.

✕Not SupportedIt is unlikely that a molecule commonly present in foods central to human existence for millions of years would be inherently bad for us.

◐Partially SupportedHigh sources of Neu5gc include animal foods such as chicken, turkey, duck, cow's milk, goat's milk, and red meat.

◐Partially SupportedAnimal studies involving knockout mice that were given Neu5gc showed higher rates of cancer and generated anti-Neu5gc antibodies.

✕Not SupportedMany in the medical and nutritional space lack an evolutionary framework to assess food components like Neu5Gc.

✕Not SupportedCompounds like choline and carnitine are sometimes subjects of fear-mongering.

✕Not SupportedThe claim that Neu5gc is problematic is unsubstantiated, as evidenced by species that consume Neu5gc-rich diets without widespread cancer or extinction.

◐Partially SupportedDietary components like choline and carnitine are not bad for humans and are indispensable parts of human evolution.