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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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How Genes Shape Your Risk Taking & Morals | Dr. Kathryn Paige Harden — Whalespan

Content›Video›How Genes Shape Your Risk Ta…

How Genes Shape Your Risk Taking & Morals | Dr. Kathryn Paige Harden

Andrew Huberman2h 42m · 2026-02-09

Claims Made

217

Claims Supported

149

Support Rate

69%

Support rate

149 of 217 claims supported

149 supported68 partial / not

Claims from this content

80

✓Well SupportedMattress characteristics like softness, firmness, and breathability significantly impact sleep quality and should be tailored to individual needs.✕Not SupportedNon-stick pans can contain toxic compounds like PFAS, which are linked to hormone disruption, gut microbiome disruption, and fertility problems.✓Well SupportedAGZ is a sleep supplement that provides excellent sleep quality, leading to waking up more refreshed.✓Well SupportedOur Place's Always Pan Pro is a non-stick pan made of pure titanium without chemicals or coatings, free from PFAS and other harmful chemicals.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Real-time glucose monitoring can help individuals develop eating and lifestyle habits that support metabolic health, mental clarity, and sustained energy.

✓Well SupportedAG1 is offering a free bottle of vitamin D3 K2, a bottle of omega-3 fish oil capsules, and a sample pack of AGZ with the first subscription to AG1.

✓Well SupportedMale friendships involve teasing in front of each other but not behind their backs, and friends defend each other externally.

✓Well SupportedTherapy can be beneficial even on days when one does not feel like doing it.

✓Well SupportedSignificant glucose spikes and crashes negatively impact cognitive and physical performance.

◐Partially SupportedBetterHelp facilitates online therapy with licensed therapists, making it easy to find a resonant therapist and fit sessions into a busy schedule.

◐Partially SupportedThe presence of a biological father can offer a protective effect against earlier puberty onset.

◐Partially SupportedGlucose levels directly impact brain function, mood, and energy levels, and may affect tenacity and willpower.

◐Partially SupportedThe brain's reward system can activate when something negative happens to a disliked person.

✓Well SupportedTaking walks around meal times can aid digestion and help lower insulin levels.

◐Partially SupportedAdoption and pedigree studies suggest genetic commonality across behaviors like addiction, risky sexual behavior, and violence.

◐Partially SupportedInsufficient sleep quality and quantity negatively impact mental health, physical health, and performance.

◐Partially SupportedGene recombination with each generation leads to significant individual differences.

◐Partially SupportedThere is genetic overlap between addiction, sexual behavior, and aggression.

◐Partially SupportedThree personality dimensions often associated with chronic, negative-consequence behaviors include sensation seeking, disinhibition, and antagonism/callousness.

◐Partially SupportedPreventing puberty in animals by over-reacting them or removing testicles does not appear to extend the critical period for neuroplasticity.

◐Partially SupportedAn epigenetic clock can measure physical maturity during puberty and correlates with aging.

◐Partially SupportedThe male bias in early-onset antisocial behavior before puberty may be due to in-utero organizing effects or factors on the Y chromosome, not post-uterine testosterone.

◐Partially SupportedHuman genotype can respond flexibly to environmental inputs, enabling adaptability.

◐Partially SupportedIndividuals with a parent or parents who have issues with alcohol should be very careful with alcohol consumption.

✕Not SupportedDelivering genetic information without correcting the perception that it defines one's deepest self can be dangerous.

◐Partially SupportedA person discovered through genetic testing that their biological father was their fertility doctor, resulting in approximately 26 half-siblings.

◐Partially SupportedOliver Burkeman advises focusing energy and attention locally rather than broadly.

◐Partially SupportedGenetic variants can increase the probability of certain behaviors.

◐Partially SupportedMen experience increasing testosterone levels into their late teens and 20s.

◐Partially SupportedFig trees can cause wasps to rot and wither away figs containing wasp eggs if the wasp is detected as a lazy pollinator.

◐Partially SupportedGenes are a significant upstream factor influencing behavior.

◐Partially SupportedPunishment is not the most effective method for improving children's behavior, though consequences, accountability, and boundaries are necessary.

◐Partially SupportedIndividuals can break negative cycles of behavior within a single generation, independent of genetics.

◐Partially SupportedDiscovering unknown relatives through genetic testing can cause significant psychological distress and reframe one's identity.

◐Partially SupportedThe age at which puberty begins has been decreasing with each successive generation.

◐Partially SupportedBehaviors associated with the seven deadly sins can be scientifically operationalized as engaging in pleasurable short-term activities with negative long-term consequences.

◐Partially SupportedGenes from parents, combined with generational or childhood trauma, can contribute to predispositions for behaviors like addiction.

◐Partially SupportedHumans are highly attuned to the feeling of being excluded from a group because it ancestrally signified death.

◐Partially SupportedGenes that predict physical aggression in boys also predict relational aggression in girls.

◐Partially SupportedWhile men die earlier on average, the difference in healthspan between men and women is less pronounced than the difference in lifespan.

◐Partially SupportedPeople may infer genetic predispositions from family history and adjust their behavior accordingly.

◐Partially SupportedAdolescence is a period where individual differences in life trajectories become apparent and deepen, influenced by the interaction of genes and family environments.

◐Partially SupportedTransgenerational trauma can be transmitted through genes and experience.

◐Partially SupportedThe hypothalamus is involved in driving hunger, sex behavior, thirst, aggression, and other behaviors.

◐Partially SupportedChildren with conduct disorder before age 10 have a 50-75% likelihood of developing a substance use disorder in adulthood.

◐Partially SupportedChildren who are spanked do not behave better than children who are not spanked, and may behave worse.

◐Partially SupportedThere is a strong genetic component to the timing of puberty in both boys and girls, alongside environmental influences.

◐Partially SupportedEffective dog training involves firmness, boundaries, and rewarding desired behavior, not harsh punishment or pain.

◐Partially SupportedObserving someone else being harmed activates empathy and causes a negative physiological response.

◐Partially SupportedPunishment is less effective than rewarding desired behaviors for shaping behavior.

◐Partially SupportedGenetic predispositions towards disinhibition and problems with self-regulation manifest similarly in men and women, with primary difference being higher rates in men.

◐Partially SupportedDopamine may function as a universal currency of reward, with drops in dopamine potentially acting as punishment and increases as reward.

◐Partially SupportedGenetic differences become more predictive of phenotype in adulthood as individuals select environments based on their genetic temperament.

◐Partially SupportedGenes associated with addiction and impulsivity are polygenic and most highly expressed during neurodevelopment in the second and third trimesters of gestation.

◐Partially SupportedA rare MAOA gene mutation on the X chromosome in a Dutch family was linked to criminal behavior in affected men.

◐Partially SupportedThe balance between the inhibitory GABA system and excitatory glutamate system during fetal development appears to influence the brain's inhibition-excitation balance, which is implicated in behavioral disorders.

◐Partially SupportedHeritability estimates for cognition and intelligence increase with age, peaking around age 12.

◐Partially SupportedEpigenetic clocks measured by DNA methylation predict shorter lifespan and worse health.

◐Partially SupportedGenetically engineering mice to enter puberty earlier results in a shorter lifespan.

◐Partially SupportedPolygenic scores are not precise enough to predict specific risk for outcomes like alcohol use disorder.

◐Partially SupportedLearning from peers, sensitivity to risk, and certain emotions are tied more to pubertal development than to age.

◐Partially SupportedNeuroplasticity available around puberty is significantly greater than in a 30 or 40-year-old.

✕Not SupportedThe notion that puberty and testosterone activation turn a 'sweet kid' into a 'bad kid' is not true.

◐Partially SupportedMeeting a potential partner's parents can provide insights into their family's traits and potential for pathology.

◐Partially SupportedEnvironmental factors like sunlight exposure and day length can impact gene expression and influence trait development.

◐Partially SupportedHumans are complex, and behaviors are multifaceted, meaning individuals cannot be reduced to a single gene or phenotype.

◐Partially SupportedCognitive functions such as executive function, attention shifting, and updating appear more age-related than pubertal development.

◐Partially SupportedThe sex ratio of children younger than 10 showing antisocial behavior ranges from 2:1 to 4:1 male to female.

◐Partially SupportedGetting a great night's sleep is foundational for mental health, physical health, and performance.

◐Partially SupportedAddictive behaviors may relate to an imbalance in brain excitation and inhibition.

◐Partially SupportedHuman girls raised with a nonbiological father tend to enter puberty earlier on average.

◐Partially SupportedSome individuals with substance use disorders report that certain substances help them feel 'normal'.

◐Partially SupportedEarly onset of puberty in girls is a predictor of increased risk for mental health problems, physical health problems, earlier menopause, and shorter lifespan.

◐Partially SupportedGenetic predispositions and early life trauma jointly shape brain development, personality, and subsequent behavioral struggles.

◐Partially SupportedThere is a trade-off between reproductive maturity and lifespan across species and at a molecular level within species.

◐Partially SupportedClinical psychology identifies diagnoses characterized by impulsive, immediately pleasurable behaviors that are long-term harmful, such as substance use disorders and conduct disorder.

◐Partially SupportedGenetic liabilities for disinhibition and problems with self-regulation manifest consistently between men and women.

◐Partially SupportedRelational aggression is as painful as physical aggression.

◐Partially SupportedMen's cortisol levels may return to baseline faster than women's after a marital argument.

◐Partially SupportedPunishing bad behavior in children can sometimes lead to an increase in the behavior.