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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Which lab tests can tell you about lifespan? (AMA #1) — Whalespan

Content›Video›Which lab tests can tell you…

Which lab tests can tell you about lifespan? (AMA #1)

Peter Attia8m · 2020-01-18

Claims Made

24

Claims Supported

24

Support Rate

100%

Support rate

24 of 24 claims supported

24 supported0 partial / not

Claims from this content

22

✓Well SupportedMeasuring insulin response alongside glucose levels provides a more complete picture of insulin sensitivity than glucose levels alone.✓Well SupportedA fasting glucose of 82 mg/dL does not necessarily indicate normal insulin levels, as insulin can be elevated without a corresponding rise in glucose.✓Well SupportedFasting insulin levels are important for assessing metabolic health, especially for individuals on carbohydrate-restricted diets.✓Well SupportedElevated ADMA/SDMA may impair nitric oxide synthase, reducing nitric oxide production and leading to vasodilation.

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓Well Supported

Imaging of the heart's blood vessels, such as a CAC scan or CT coronary angiogram, is crucial and more informative than blood work alone for assessing atherosclerosis risk.

✓Well SupportedBlood tests currently offer limited insight into cancer risk, except for future liquid biopsies detecting RNA, DNA, or proteins.

✓Well SupportedInflammation markers like fibrinogen, C-reactive protein, ox-LDL, and ox-PLAP-2 can be measured in blood to assess cardiovascular risk.

◐Partially SupportedLpa levels drop by half until age 80 and then increase in centenarians, suggesting a protective role in aging.

◐Partially SupportedMinimizing hyperinsulinemia is important for cancer risk reduction.

✓Well SupportedFasting glucose levels above 150 mg/dL clearly indicate a problem, but values between 105-150 mg/dL are less informative regarding insulin sensitivity.

◐Partially SupportedFasting glucose variations between 90 and 105 mg/dL are more likely influenced by cortisol levels than by insulin sensitivity.

◐Partially SupportedHigh insulin levels can be toxic to the endothelium and myocardium.

◐Partially SupportedA low-carb diet can impair glucose tolerance, which can be reversed by consuming 150 grams of carbohydrates daily for three days.

◐Partially SupportedImproving the cardio-metabolic profile can positively impact Alzheimer's disease risk due to its vascular component.

◐Partially SupportedToxins are a significant but difficult-to-measure factor in neurodegenerative disease risk.

◐Partially SupportedFor a 40-year-old without extreme Lp(a) levels, blood tests provide 80-85% of the information for assessing cardiovascular disease risk.

◐Partially SupportedBlood tests can measure lipoprotein markers such as LP(a), LDL particle number, and VLDL for cardiovascular risk assessment.

◐Partially SupportedReferral to Richard Isaacson's clinic at Cornell for potential lumbar punctures and CSF marker analysis is an option for very high-risk Alzheimer's patients.

◐Partially SupportedAlzheimer's disease risk stratification can be informed by ApoE genotype, vascular risk factors, and metabolic health.

◐Partially SupportedCardiovascular disease risk can be assessed by evaluating lipoproteins, inflammation, and endothelial dysfunction.

◐Partially SupportedBlood tests can assess risk for atherosclerosis, stroke, cancer, and neurodegenerative diseases.

◐Partially SupportedCancer risk is primarily determined by somatic mutations, not germline mutations, making genotype testing generally unhelpful except for rare outliers.