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Weekly · Sunday Morning

Five longevity claims.
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Every Sunday.

Last Sunday

Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Does mTOR Shorten Lifespan? — Whalespan

Content›Video›Does mTOR Shorten Lifespan?…

Does mTOR Shorten Lifespan?

Paul Saladino2m · 2025-02-16

Claims Made

10

Claims Supported

8

Support Rate

80%

Support rate

8 of 10 claims supported

8 supported2 partial / not

Claims from this content

9

✓Well SupportedFor men, a protein intake of approximately 1 gram per pound of body weight per day is recommended, while for women, it's about 0.9 grams per pound of body weight.✓Well SupportedPlant-based protein is at least twice less bioavailable than animal protein.✓Well SupportedPaul Saladino feels best when consuming approximately 220-240 grams of protein per day, which is about two pounds of meat plus a few ounces of organs.✓Well SupportedA protein intake of 0.7-0.8 grams per pound of lean body mass can support maintaining lean muscle mass without muscle loss.Well Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Exercise and physical activity activate mTOR in skeletal muscle, which is beneficial for muscle protein synthesis.

◐Partially SupportedMammalian target of rapamycin (mTOR) is critically important for muscle, vitality, longevity, stability, and libido, and fear-mongering around mTOR is unwarranted.

◐Partially SupportedDiets high in carbohydrates or mixed carbohydrates and protein trigger insulin secretion and mTOR.

✕Not SupportedExcessive rapamycin intake is harmful to humans.

◐Partially SupportedIndividuals with deficient mTOR function may exhibit weakness and a 'mushy' physique.