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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Is fructose addictive? — Whalespan

Content›Video›Is fructose addictive?…

Is fructose addictive?

Paul Saladino13m · 2024-02-02

Claims Made

27

Claims Supported

22

Support Rate

81%

Support rate

22 of 27 claims supported

22 supported5 partial / not

Claims from this content

18

✓Well SupportedBlood glucose levels after consuming whole oranges or orange juice (matched for carbohydrates) are roughly the same, indicating similar carbohydrate absorption.✓Well SupportedBerries are low in fructose and contain fiber, which mitigates fructose absorption and feeds the gut microbiome.✓Well SupportedSugar and high fructose corn syrup activate dopamine reward centers in a child's brain similarly to an adult drug addict.✓Well SupportedFiber may be beneficial when consuming fructose as it can slow absorption and allow the small intestine to process it more effectively.Well Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Fructose is present in our diets as an evolutionary holdover from primate ancestors, lacking current value for the organism.

✓Well SupportedThe intestine compensates for delayed nutrient absorption from soluble fiber by spending more time processing food.

✓Well SupportedIncreases in dopamine associated with sweet taste or blood glucose-elevating foods activate the nucleus accumbens and arcuate nuclei.

✓Well SupportedFructose from whole fruits like berries or bananas is better than fructose in juice form due to fiber content slowing glucose spikes.

✓Well SupportedCarbohydrates consumed with fiber do not significantly impact or spike blood glucose.

✕Not SupportedFiber does not significantly inhibit the absorption of fructose or glucose.

✓Well SupportedFructose is not biochemically required by any vertebrate.

◐Partially SupportedSteak can activate the nucleus accumbens, with high-quality steak activating it more than low-quality steak.

✕Not SupportedRodent models using intermittent access to food (12 hours deprivation, 12 hours ad libitum) are problematic for inducing binging behavior due to rat physiology.

✕Not SupportedImplying fructose is negative solely because it induces dopaminergic signaling in the nucleus accumbens is tenuous, given that glucose and fats also activate these pathways and are essential for energy.

◐Partially SupportedThe appendix may serve a function as a repository for bacterial cultures.

◐Partially SupportedAndrew Huberman eating eight ounces of blueberries would consume approximately 10 grams of fructose.

◐Partially SupportedActivation of the nucleus accumbens does not inherently mean a substance is negative, as glucose and fats also stimulate this area.

◐Partially SupportedFructose activates brain areas linked to reward and seeking behaviors.