Controversial Thoughts, 7/4: Omega-3, CLA, and media bias!

PS

Paul Saladino21m · 2020-07-04

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39

Claims Supported

30

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77%

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30 of 39 claims supported

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34

Well SupportedExcessive lipolysis and broken fat cells, potentially caused by polyunsaturated fatty acid breakdown products like linoleic acid, can lead to insulin resistance.Well SupportedIndigenous populations studied typically consume diets where linoleic acid constitutes about 2% of fat intake, contrasting with 7-15% in Western diets.Well SupportedChickens and pigs are typically fed diets higher in linoleic acid than they would consume in the wild.Well SupportedPork fat from pigs fed corn and soy can contain 10-15% or more linoleic acid, compared to wild pigs with around 4-5%.Well Supported

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Most individuals can obtain sufficient omega-3 fatty acids from grass-fed animal fats like suet or tallow, negating the need for excessive omega-3 consumption.

Well SupportedLinoleic acid intake should ideally be kept below five grams per day, and potentially even below four grams per day.

Partially SupportedApproximately 5% of alpha-linolenic acid (ALA) is converted to EPA, and less than 0.5% to DHA.

Partially SupportedConjugated linoleic acids (CLAs) are a family of 28 isomers of linoleic acid found in meat and dairy from ruminants.

Not SupportedHigh intake of fish oil supplementation may lead to increased lipid peroxidation.

Not SupportedHigh doses of omega-3 supplementation (e.g., 3 grams) are likely unnecessary for individuals on a low linoleic acid diet.

Partially SupportedDietary linoleic acid is required for the development of experimentally induced alcoholic liver injury in rats.

Partially SupportedSupplementing with omega-3 fatty acids can increase lipid peroxidation, even when co-administered with vitamin E.

Partially SupportedHigh intake of linoleic acid disrupts metabolism, and adding oily fish may increase lipid peroxides.

Partially SupportedA robust amount of EPA and DHA is important and can be obtained from fish, grass-fed animal fat, and egg yolks.

Partially SupportedOmega-3 supplementation can increase lipid peroxidation even when supplemented with vitamin E.

Partially SupportedThe omega-6 to omega-3 ratio in the diet is important, with an ideal target of close to 1:1.

Partially SupportedHumans require a small amount of omega-3 in their diet, obtainable from animal fat sources.

Partially SupportedNews sources in the middle of the media bias chart, such as AP, Reuters, and The Economist, are generally more reliable and less biased than those at the extremes.

Partially SupportedEvolutionary evidence suggests humans historically consumed very low amounts of polyunsaturated fats.

Partially SupportedPlant-derived trans fats like elaidic acid are harmful, while some animal-derived trans fats like CLA and acetic acid may be beneficial.

Well SupportedAvoiding refined carbohydrates and sugars, ensuring adequate exercise, and not overeating are more critical health priorities than fearing linoleic acid.

Partially SupportedDysregulation of the hypothalamus due to excess linoleic acid may contribute to obesity and inflammation.

Partially SupportedOmega-3 supplementation may only be useful for individuals with very high linoleic acid intake, but it could also increase lipid peroxidation.

Partially SupportedExcess linoleic acid, not phytosterols, is likely responsible for hypothalamic dysregulation observed in soybean oil studies.

Partially SupportedConsuming fatty fish may increase insulin sensitivity compared to a red meat diet, particularly in iron-deficient women.

Not SupportedTrans fats from hydrogenated vegetable oils are detrimental to human health.

Partially SupportedThe position of double bonds in polyunsaturated fatty acids significantly impacts their activity in the human body.

Partially SupportedExcess linoleic acid, when imbalanced by omega-3s, can cause overeating in mice by increasing endocannabinoids.

Partially SupportedDiets with over 10% of fat calories from linoleic acid may show improvements in insulin sensitivity when supplemented with polyunsaturated fatty acids from real food, but may also increase lipid peroxidation.

Partially SupportedLinoleic acid is an omega-6 polyunsaturated fatty acid with double bonds at the 9 and 12 positions.

Partially SupportedSoybean oil, high in linoleic acid, significantly disrupts hypothalamic biology in mice, affecting inflammation, neuroendocrine function, and insulin signaling.

Partially SupportedBalancing omega-6 with omega-3 fatty acids is important for metabolic health.

Partially SupportedFruit consumption, such as watermelon during its season, is reasonable within a tier-one carnivore diet.

Partially SupportedConjugated linoleic acid (CLA) should not be feared.