Does protein cause CANCER?? With Dr. Gabrielle Lyon

PS

Paul Saladino1h 28m · 2020-01-07

Claims Made

146

Claims Supported

100

Support Rate

68%

Support rate

100 of 146 claims supported

100 supported46 partial / not

Claims from this content

111

Well SupportedVegans and vegetarians may be deficient in creatine, leading to cognitive impairment, as supplementation has been shown to improve cognitive function in these groups.Well SupportedFor healthy, active individuals, 20 grams of protein per meal is optimal for maximizing muscle protein synthesis for up to four to five hours post-meal.Well SupportedAncestral Supplements produces freeze-dried organ meat supplements in convenient gelatin capsules, sourced from grass-fed, grass-finished animals in New Zealand.Well SupportedObtaining 2.6 grams of leucine from plant-based foods like lentils or beans requires consuming nearly half a pound of these foods.

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well Supported

Older adults (65+) require double the amount of protein intake compared to younger adults for the same rate of muscle protein synthesis.

Well SupportedNose-to-tail eating is a recommended approach.

Well SupportedThe leucine content of food is the primary factor for triggering muscle synthesis, not just the total protein amount.

Well SupportedReducing meal frequency to two to three meals per day supports muscle protein synthesis, maintenance, strength, insulin sensitivity, and metabolic health.

Well SupportedMaintaining high lean muscle mass is likely more beneficial for health than being slightly leaner with lower muscle mass.

Well SupportedAlzheimer's disease is referred to as 'type 3 diabetes' due to similarities with brain diabetes.

Well SupportedThere is a postprandial rise in insulin when eating protein, even on a ketogenic diet, but it is significantly lower than in a non-ketogenic state.

Well SupportedLower vitamin B12 levels in elderly adults are correlated with smaller brain size.

Well SupportedPopulations with an average fasting insulin of 8.6 ng/mL and 15.7 ng/mL, respectively, are likely insulin resistant.

Not SupportedFor individuals in their 60s and older, continuing to fast may negatively impact muscle health, making the first meal of the day important.

Well SupportedAs individuals age, they develop anabolic resistance, requiring more protein over time for the same anabolic stimulus.

Well SupportedFructoseamine measures average blood glucose over 2-3 weeks and can correlate with Hemoglobin A1C.

Well SupportedMaintaining an amino acid reserve through muscle mass is crucial for older adults to improve recovery and reduce mortality risk.

Well SupportedProtein powder is a practical option for elderly individuals struggling to meet daily protein requirements.

Well SupportedDisuse atrophy events, such as those following surgery, falls, or illness, can lead to catastrophic and often irreversible muscle loss, particularly in older adults.

Not SupportedThe recommended daily allowance of 0.8 grams of protein per kilogram of body weight is insufficient for building and maintaining muscle mass in aging individuals.

Well SupportedVitamin B12 obtained from soil contains analogs that are ineffective for human cognition.

Well SupportedInsulin stimulates mTOR more significantly and for a longer duration than leucine.

Well SupportedInsulin resistance and obesity are significant contributors to cancer risk alongside smoking.

Well SupportedStress or intense exercise can cause temporary spikes in blood glucose levels, even for individuals adhering to a ketogenic diet.

Well SupportedExercise and physical activity activate mTOR in skeletal muscle, which is beneficial for muscle protein synthesis.

Partially SupportedKeto-adapted individuals may have a lower insulin response to protein due to a different physiologic switch involving the insulin-glucagon ratio.

Well SupportedAim for approximately 2.6 grams of leucine per meal, especially for aging individuals.

Partially SupportedThere is no significant difference in gut alpha diversity between individuals on an entirely animal-based diet and those on a plant-based diet.

Partially SupportedHigher fasting blood glucose levels on a carnivore diet may be related to high protein intake.

Well SupportedMuscle mass is directly related to mortality and morbidity.

Well SupportedSarcopenia, or the loss of muscle mass with age, is a precursor to frailty and is predictive of decline.

Partially SupportedAdequate protein intake in carb-free diets can sufficiently fill glycogen stores, potentially supporting athletic performance.

Well SupportedThe protein requirement for maintaining tissue and stimulating muscle building is the same for men and women, based on blood volume and lean muscle mass.

Partially SupportedCortisol levels tend to remain slightly higher in individuals following ketogenic or high-protein/carnivore diets compared to other dietary patterns.

Partially SupportedLoss of lean muscle mass is a frequent cause of death in cancer patients and can lead to mortality during hospital recovery.

Partially SupportedAdequate intake of branched-chain amino acids, particularly leucine per meal, is essential for muscle protein synthesis and healthy muscle.

Well SupportedMuscle-centric medicine posits that skeletal muscle is the primary determinant of health and wellness.

Partially SupportedTraditional medical ketogenic diets for epilepsy typically have a 4:1 fat-to-protein ratio and can lead to inadequate protein intake and potential acid-base balance issues.

Partially SupportedInsufficient protein intake leads to loss of lean muscle mass.

Partially SupportedA ketogenic diet may increase red blood cell lifespan, potentially affecting hemoglobin A1c readings.

Well SupportedThe leucine threshold for stimulating muscle protein synthesis is not dependent on body size, but rather on blood volume.

Partially SupportedAnimal foods were historically considered superfoods that fueled human evolution and brain growth.

Not SupportedThe RDA of 0.8 grams of protein per kilogram of body weight is a bare minimum requirement to prevent disease, not an optimal amount.

Partially SupportedMonocrop agriculture, particularly plant-based systems, depletes soil nutrients and necessitates the use of phosphorus and nitrogen-based fertilizers.

Partially SupportedWhite Oak Pastures offers grass-fed, grass-finished lamb, beef, duck, and Iberian hogs.

Partially SupportedOrgan meats, such as chicken liver, are among the most nutritious and inexpensive foods available.

Not SupportedThe claim that protein intake is a significant risk factor for cancer is not supported by data, with relative risks around 1.2-1.3.

Partially SupportedA carnivore diet is often ketogenic, but can vary in the degree of ketosis based on macronutrient ratios.

Partially SupportedProtein stimulates insulin release to a much lesser extent than carbohydrates, and this insulin response from protein is further reduced in a ketogenic or fat-adapted state.

Partially SupportedBeef is a nutrient-dense 'superfood' containing essential nutrients like zinc, B12, carnitine, choline, and carnosine.

Partially SupportedThe morning cortisol awakening response (CAR) may be higher in individuals on higher protein diets.

Partially SupportedHigh-quality protein intake is beneficial for young individuals, especially those with body composition issues.

Partially SupportedMidlife obesity leads to later-life aging issues including dementia and Alzheimer's.

Partially SupportedA smaller brain size is associated with detrimental neuronal atrophy.

Partially SupportedGabrielle Lyon has a weekly newsletter with evidence-based information.

Not SupportedPromoting plant-based proteins as the primary source for aging individuals is poor advice.

Partially SupportedMany women experience thyroid and hormonal issues after an initial 'honeymoon phase' on a ketogenic diet.

Partially SupportedCancer cachexia involves the loss of mass through an inflammatory process.

Not SupportedThe recommendation to limit animal protein intake as one ages is dangerous.

Partially SupportedAdapting to carbohydrates for a few days before an OGTT yields a more accurate reflection of physiological insulin resistance.

Partially SupportedAn oral glucose tolerance test or fasting insulin level provides a better evaluation of glucose metabolism than fructosamine or CGM alone.

Partially SupportedObesity and hyperinsulinemia are risk factors for cancer.

Partially SupportedMuscle is the organ of longevity and is a key organ in insulin resistance.

Partially SupportedA diet primarily consisting of ground bison and eggs is a simple and effective approach to nutrition.

Partially SupportedA wider waistline is correlated with lower brain volume.

Partially SupportedConsuming a steak or hamburger for breakfast could significantly alter the trajectory of aging.

Partially SupportedA meat-based diet is not inherently low-carb because the body can generate glucose from protein.

Partially SupportedWhite Oak Pastures offers organs and bones for bone meal, bone marrow, or stock.

Partially SupportedIndustry-funded studies are 4-6 times more likely to find favorable results.

Partially SupportedYounger individuals may tolerate sub-optimal protein intake due to hormonal influences, but this flexibility diminishes with age.

Partially SupportedDuring SEAL deployments, high protein intake from real, whole foods correlated with performance.

Partially SupportedProtein sparing modified fasts are low-calorie, high-protein diets supplemented with essential fatty acids, intended for rapid weight loss under practitioner supervision.

Not SupportedPlant-based diets may not be sustainable for older adults due to potential deficiencies in essential amino acids like methionine.

Partially SupportedWhey protein is preferable to egg and fruit for individuals with dairy sensitivity.

Not SupportedA vegan diet was unsustainable for a SEAL on deployment in Africa, leading to performance decline and a return to a meat-inclusive diet within a week.

Partially SupportedMuscle protein synthesis and biogenesis are driven by hormonal milieu and stimulated by resistance training and protein intake, becoming more challenging with age.

Partially SupportedSome proponents advocate avoiding animal protein to prevent excessive mTOR activation, which they claim depletes the amino acid reservoir.

Partially SupportedAnabolic resistance, the concept that more protein is needed to trigger mTOR, increases with age, inflammation, obesity, and poor muscle health.

Partially SupportedMuscle protein synthesis serves as a maintenance signal for muscles, indicating they are needed and should be preserved.

Partially SupportedA carnivore diet requires only about 4 grams of essential fatty acids.

Partially SupportedSkipping or consuming a high-carbohydrate breakfast can increase later cravings by affecting neurotransmitters.

Partially SupportedLeucine is a critical amino acid for triggering physiological responses.

Not SupportedThe assertion that animal protein directly leads to cancer is unsubstantiated and based on faulty evidence.

Partially SupportedSupplementation with lutein and zeaxanthin may be valuable for individuals on a meat-based diet.

Partially SupportedMidlife obesity and high carbohydrate intake, particularly from wheat, are significant contributors to cognitive decline.

Partially SupportedDwarfs with growth hormone receptor deficiency and low IGF-1 do not have cancer but exhibit severe metabolic and hormonal disturbances, including sleep problems and insulin resistance.

Partially SupportedThe definition of 'ketogenic diet' is broad and can encompass very high-fat diets, medical ketogenic diets, low-carb diets, and protein-sparing fasts, leading to potential confusion in research interpretation.

Partially SupportedInsufficient protein intake may be a significant stressor and trigger for hormonal imbalances, particularly in women on ketogenic diets.

Partially SupportedHigh-fat ketogenic diets, where over 70% of calories come from fat, may be associated with negative physiological effects.

Partially SupportedVegans and vegetarians have, on average, a brain size that is one standard deviation lower than omnivores.

Partially SupportedNeglecting fat in the diet can lead to deficiencies in fat-soluble vitamins.

Not SupportedOverextending a protein sparing modified fast can potentially lead to hormonal issues.

Partially SupportedProtein intake, especially below 40 grams, stimulates a phase one insulin release which is necessary for muscle growth and does not negatively impact mTOR stimulation.

Partially SupportedSarcopenia can prevent recovery from events like hip fractures.

Partially SupportedAs individuals age, their protein requirements increase to trigger a physiological response.

Partially SupportedFor aging parents, consuming three to four ounces of meat in the morning, and potentially two to three times daily, is recommended to maintain muscle mass and support recovery.

Partially SupportedFor individuals with dairy sensitivity, consuming meat (e.g., four ounces of ground meat) may be a necessary alternative to whey protein.

Partially SupportedProtein requirements for aging individuals can involve sharp losses of muscle mass following illness or injury.

Partially SupportedA high-protein meal in the morning positively affects satiety and reduces the likelihood of bingeing or overeating later in the day.

Partially SupportedHigh protein intake is more likely to lead away from obesity.

Partially SupportedIt is biologically impossible to equate the protein quality and leucine content of a peanut butter sandwich to that of beef.

Partially SupportedThere is no evidence that protein initiates cancer.

Partially SupportedAn oral glucose tolerance test may yield a failed result in individuals recently transitioned from a carnivore or very low-carbohydrate diet due to lack of adaptation.

Partially SupportedUltraviolet light can increase gut microbiota diversity.

Partially SupportedThe quality of protein and its amino acid profile are objective and non-arguable scientific facts.

Partially SupportedMuscle protein synthesis and biogenesis are driven by hormones in youth, and by resistance training and protein intake with age.

Not SupportedThe assertion that older adults, particularly women, should avoid stimulating mTOR is incorrect.

Partially SupportedIndividuals on higher protein diets can maintain stable blood sugar through gluconeogenesis, resulting in low fasting insulin but potentially higher hemoglobin A1c.

Partially SupportedThe speaker's current diet includes coffee with five or six eggs and ground beef or bison in the morning, with oats and sweet potatoes as preferred carbohydrates.

Partially SupportedThe microbiome may play a role in plant-based diets by extracting and generating amino acids and making them available to the host when bacteria die.

Partially SupportedIndividuals who thrive long-term on vegan diets likely have unique bio-individuality and microbiome capacity.