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I Answered Your Questions For 95 Minutes

PS

Paul Saladino1h 36m · 2025-09-10

Support Rate

70%

151 of 217 claims supported

Support rate

151 of 217 claims supported

151 supported66 partial / not

Claims from this content

157

Well SupportedTaurine is a unique nutrient found in animal foods, not plant foods, and has been studied for longevity benefits across multiple species.Well SupportedA basic lipid panel with apolipoprotein B (apoB) is sufficient for assessment when interpreted in the context of insulin sensitivity and fasting insulin levels.Well SupportedInfrared light is used in mitochondria to produce melatonin, which acts as a systemic antioxidant, and many people are systemically deficient in melatonin.Not SupportedLow-level alcohol consumption (1-2 drinks per day) over time can lead to neocortical thinning, brain atrophy, and increased gut permeability.Well SupportedMost people will feel better when they increase their protein intake to one gram per pound of body weight, which can also increase bone density.

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well SupportedManaging iron levels through phlebotomy can decrease sex hormone-binding globulin (SHBG) levels.

Well SupportedMeat and organs contain unique nutrients like taurine and creatine, and deficiencies in these are not well-quantified.

Well SupportedTraditional Finnish saunas are preferred over infrared saunas because they feel better and are hotter.

Well SupportedA comprehensive blood work panel should include inflammatory markers, fasting insulin, lipids, thyroid hormones, sex hormones, PTH, cortisol, c-peptide, CBC, and CMP.

Partially SupportedThe speaker experienced palpitations, leg cramps, and sleep disturbances while on a carnivore diet before reintroducing carbohydrates.

Well SupportedFructose from fruit is not significantly harmful to humans and may be a beneficial component of a healthy diet.

Partially SupportedInsulin sensitivity below 5, preferably below 3, makes LDL particle number, LDL size, and related metrics less significant.

Not SupportedMainstream cardiology largely ignores data suggesting the connection between ApoB and heart disease is significantly attenuated in the context of insulin sensitivity.

Partially SupportedPolyunsaturated fats may increase oxidized LDL and Lp(a), while saturated fat and animal foods are often blamed for raising LDL.

Not SupportedThe long-term mortality benefits of statins, particularly for primary prevention, are questionable and may not address the root cause of cardiovascular disease.

Well SupportedIf an individual is insulin sensitive (fasting insulin < 5, preferably < 3), then LDL particle number, LDL size, and Lp(a) are less concerning for cardiovascular risk.

Well SupportedHeart and Soil Supplements offers a female supplement called 'Her Package' containing uterus, fallopian tubes, ovary, kidney, and liver.

Well SupportedThe quality of calories consumed significantly affects metabolism and the body's ability to burn calories.

Well SupportedMeats, poultry, and seafood are rich sources of zinc.

Well SupportedOdd-chain fatty acids (C15 and C17) may protect cell membranes against oxidative stress and ferroptosis.

Well SupportedSauna use can increase blood glucose levels due to dehydration and water loss.

Partially SupportedRegenerative agriculture can help the Earth inhale atmospheric carbon back into the soil, potentially leading to increased plant life and greenery.

Partially SupportedSaunas are stressful and can be used to one's advantage or detriment depending on overuse.

Partially SupportedExercise benefits the brain by increasing blood flow, oxygen supply, and brain-derived neurotrophic factors (BDNF), promoting brain growth.

Not SupportedOverusing sauna when experiencing high allostatic load may negate net benefits.

Partially SupportedSauna use may help stabilize heart rate variability during the luteal phase.

Well SupportedMethylated B vitamins, including methyl B12, methyl folate, trimethylglycine, and methionine, are the best way to lower elevated homocysteine levels.

Well SupportedFerroptosis is a form of cell death involving hydrogen peroxide, free iron, and lipids.

Partially SupportedLiver is the best source of copper, with insignificant amounts in muscle meat and questionable bioavailability in mushrooms.

Partially SupportedSteaks at restaurants can be requested to be cooked without seed oils, for example, on a grill or in tallow.

Partially SupportedEating meat from nutrient-rich animals, particularly from regenerative agriculture sources, is nutritionally superior.

Well SupportedMany meat-centric cultures with higher rates of centenarians were excluded from Blue Zones research.

Partially SupportedA comprehensive assessment of metabolic health should include a thyroid panel and fasting insulin levels.

Not SupportedInterpreting blood lipid levels without considering fasting insulin or hormonal health is considered malpractice.

Partially SupportedThe Animal-Based Nutrition Research Foundation (ABNRF) plans to conduct randomized controlled trials comparing animal-based diets, plant-based diets, and AHA diets for autoimmune conditions.

Partially SupportedElevated HRV is generally a high-level indicator of readiness and recovery, and higher HRV is desirable.

Partially SupportedMeat consumption is positively correlated with longevity and there is no solid evidence that meat shortens lifespan.

Partially SupportedMonitoring thyroid function and body temperature is important when implementing fasting or carbohydrate restriction, as these can indicate a slowing metabolism.

Limited ResearchSauna may offer unique benefits for detoxification, but its benefits for longevity are questionable if one is already highly active.

Not SupportedThe GRAS standards from the FDA allow thousands of ingredients that have not been checked for long-term safety.

Partially SupportedAn animal-based diet can improve diabetes within eight weeks.

Partially SupportedNeurotransmitter synthesis requires co-factors primarily found in animal foods like red meat, egg yolks, and liver.

Well SupportedAdding carbohydrates to a carnivore diet can lead to a decrease in fasting blood sugar and hemoglobin A1C levels.

Partially SupportedSome salts contain significant amounts of heavy metals if consumed at 8-10 grams per day.

Partially SupportedAnimal-based diets result in significantly more nutrient-rich food for humans and less loss of animal life than plants grown through monocrop agriculture.

Partially SupportedVegetable oil used in restaurants is often seed oils.

Partially SupportedInsufficient insulin signaling at the kidney can lead to electrolyte imbalances in individuals on ketogenic diets.

Partially SupportedSaunas can provide a workout-like benefit for sedentary individuals by inducing a physiological stress response without physical exertion.

Partially SupportedHS-CRP is an important molecule to measure for a cardio-metabolic profile.

Partially SupportedHuman biology and physiology are largely unchanged over tens to hundreds of thousands of years, creating discordance with modern environments.

Partially SupportedSerum ferritin levels in middle-aged men have increased over the last 30 years.

Well SupportedVitamin B6 affects the conversion of tryptophan to serotonin, and magnesium acts as a GABA agonist and affects the conversion of serotonin to melatonin.

Partially SupportedFasting may be counterproductive for stimulating autophagy due to nutrient reduction and inflammation, but this may be offset by other benefits.

Partially SupportedRed 40 and Yellow 5 have evidence of causing behavioral problems in children.

Partially SupportedCold plunges can increase dopamine and catecholamines, but their long-term impact on recovery and potential for overstressing the body should be considered.

Partially SupportedAdequate hydration is essential for protein absorption and muscle maintenance.

Not SupportedHigh meat intake is not supported by good evidence to accelerate fundamental aging processes.

Partially SupportedElevated ferritin, iron saturation, and transferrin saturation may indicate problematic iron overload.

Partially SupportedIron deficiency can impair dopamine synthesis, a key neurotransmitter.

Partially SupportedCooking with animal fats is preferred over olive and avocado oils due to potential adulteration of the latter with seed oils.

Partially SupportedA keto diet combined with living in San Diego caused electrolyte insufficiency for the speaker.

Partially SupportedGluten and other allergens can worsen mental health issues, and nutrient deficiencies exacerbate them.

Partially SupportedFood prepared in fine dining restaurants often involves plastic use and cooking with seed oils.

Partially SupportedNot sleeping well can negatively impact one's ability to be a conduit for valuable ideas.

Not SupportedLowering ApoB in primary prevention populations may not improve all-cause mortality.

Partially SupportedAn individual should determine their own optimal fasting blood sugar level, considering that over-exercising can lead to elevated levels.

Partially SupportedElevated fasting blood sugar post-workout is attributed to higher cortisol levels stimulating gluconeogenesis.

Not SupportedFructose concentration in human blood is significantly lower than glucose, making its contribution to glycation negligible.

Not SupportedEncouraging ferroptosis is likely detrimental to health.

Limited ResearchExcessive exposure to summer environments may promote ferroptosis and reduce autophagy.

Limited ResearchNutrients consumed daily may trigger autophagy, though the evidence is not fully established.

Not SupportedA consistently low body temperature and suboptimal thyroid hormone levels are indicators of a slowing metabolism.

Not SupportedNutrients like glucose can trigger autophagy, challenging the narrative that fasting is required for it.

Partially SupportedThe speaker has not observed objective lab evidence indicating that living in perpetual summer is detrimental to their health, specifically regarding fasting insulin and hs-CRP levels.

Partially SupportedIndividuals living in climates further from the equator should monitor their biology, including sleep, libido, mood, body composition, and lab markers, to assess the impact of seasonal signals.

Partially SupportedA cyclic approach to environmental exposure, including travel to northern climates, may simulate seasonal changes and promote mitochondrial turnover.

Partially SupportedExcess iron accumulation can lead to iron toxicity, particularly in postmenopausal women.

Not SupportedSitting indoors all day without infrared light exposure is damaging to human health.

Partially SupportedOptimal cellular health involves abundant nutrients, avoiding toxins, and allowing natural recycling processes.

Partially SupportedAddressing nutrient deficiencies, starting with diet (red meat, egg yolks, liver) and methylated B vitamins, can significantly improve cognitive function and mental clarity.

Partially SupportedReducing ultra-processed, refined seed oils and consuming more minimally processed animal fats may improve well-being.

Partially SupportedThe ABNRF intends to test seed oils and fryer oils from restaurants for harmful lipid oxidation and peroxidation products.

Partially SupportedIndividuals with pre-existing gut issues like SIBO may not tolerate certain carbohydrates.

Partially SupportedImproving diet quality without strict calorie restriction can lead to weight loss, improved well-being, and increased fertility.

Partially SupportedConsuming carbohydrates daily contributes to feeling one's best.

Partially SupportedSuper slow, high-intensity workouts that lead to ultimate failure can require three to five days, or up to a week, to recover from.

Partially SupportedNutrient adequacy or deficiency significantly impacts mental state, and diet can improve or reverse mental health conditions like depression, anxiety, and psychotic disorders.

Partially SupportedWorking out does not necessarily cause weight loss, as people may eat more to compensate for calories burned.

Partially SupportedElevated fasting blood sugar for several days after a workout may indicate overtraining.

Partially SupportedOptimal thyroid function for longevity involves low TSH, mid-range free T3 and free T4, low reverse T3, and absence of antibodies.

Not SupportedThe speaker feels terrible for half a day after consuming seed oils.

Partially SupportedConsuming one gram of protein per pound of body weight daily from animal foods is recommended for individuals experiencing anxiety, depression, or paranoia.

Partially SupportedCombining sauna and cold plunge is beneficial, but excessive cold plunging at very low temperatures may be overstressing.

Partially SupportedInfrared light is valuable for humans, and hot rock saunas emit significant amounts of infrared light.

Partially SupportedThe general population may be overstressed and overtrained, leading to decreased HRV.

Partially SupportedFor most people, adopting a vegan and calorie-restricted, time-restricted feeding diet leads to hormonal crashes.

Partially SupportedEgg yolks are a good substitute for liver, providing choline, betaine, folate, and vitamin A.

Not SupportedAlcohol is a toxin for the body.

Partially SupportedIncreasing saturated fat and decreasing polyunsaturated fat intake, consistent with ancestral diets, can increase ApoB, decrease triglycerides, increase HDL, and improve metabolic markers.

Partially SupportedSauna use can be considered an 'executive workout' for sedentary individuals.

Partially SupportedIndividuals with 10% body fat may not need to focus on growing more muscle if mobility and speed are prioritized over size.

Partially SupportedOvermethylation may be linked to other nutrient deficiencies or sensitivities, and gut health is crucial for understanding neurotransmitter imbalances.

Partially SupportedHumans are not evolutionarily adapted to handle numerous negative voices, which can be overwhelming in modern contexts like social media.

Partially SupportedElevated LDL (ApoB) in the context of reduced oxidized LDL, lower triglycerides, higher HDL, and lower fasting insulin may not indicate increased cardiovascular risk.

Partially SupportedWhen individuals are unhealthy, their primary focus becomes regaining health, overshadowing other life aspirations.

Partially SupportedHealth is essential for experiencing more enjoyment and fun in life.

Partially SupportedNutrients like creatine and collagen are so valuable that even vegans consume them, despite the lack of vegan collagen.

Partially SupportedLowering ApoB alone may not be the full story for extending life, especially in primary prevention.

Partially SupportedFerroptosis, a type of cell death, may be triggered by winter signals and involves hemoglobin breakdown.

Partially SupportedBrian Johnson's Blueprint 5000 study data was largely hidden and never fully released.

Partially SupportedPeriods of fasting or reduced fruit availability may be necessary for humans to receive appropriate metabolic signals.

Partially SupportedFasting due to lack of food availability during natural lean seasons may have been a beneficial ancestral practice.

Partially SupportedMechanisms of saturated and polyunsaturated fats affecting ApoB and LDL do not necessarily indicate good or bad health outcomes.

Partially SupportedMaintaining connections made at gatherings is crucial for navigating a world that may not share similar health-conscious values.

Partially SupportedConsuming a moderate amount of egg yolks, such as a couple per day, is likely healthy and can compensate for avoiding liver due to copper concerns.

Not SupportedVegan creatine is not a meaningful product.

Not SupportedImproving insulin sensitivity is a primary goal for health, and current medical therapeutics do not achieve this.

Partially SupportedIndividuals sensitive to methylated B vitamins or red meat may have nutrient deficiencies in the gut that affect neurotransmitter production or breakdown.

Partially SupportedKeto and carnivore diets, when not carefully managed, can lead to loss of both fat and muscle mass.

Partially SupportedThe body performs daily cellular recycling, making 'liver cleanses' unnecessary.

Partially SupportedBaseline lab tests including fasting insulin, thyroid panel, glucose markers, and electrolytes are recommended to assess overall health.

Partially SupportedRegenerative agriculture with animal grazing enriches soil carbon content from 0.5% to 5%.

Partially SupportedHuman biology was shaped by evolving in tropical climates under endless summer conditions.

Partially SupportedAutophagy can be triggered by daily nutrient intake and does not necessarily require fasting in humans.

Partially SupportedThe optimal size for a community gathering is below 150 individuals to prevent splitting.

Partially SupportedFreezing food is acceptable from a logistical perspective, even if fresh is preferred.

Partially SupportedRemoving synthetic ingredients from food is beneficial for public health.

Partially SupportedEnsuring adequate vitamin D intake and spending time outdoors may provide benefits.

Partially SupportedLooking at the stars, surfing, or feeling small in nature can help manage stress and gain perspective.

Partially SupportedKey metabolic and hormonal lab markers to monitor include fasting insulin, testosterone, estradiol, SHBG, thyroid hormones, body temperature, and antibodies.

Partially SupportedStress, including that from intense workouts, can be part of a beneficial hormonal signaling process for gluconeogenesis.

Not SupportedContrast therapy (sauna to cold plunge) can pose cardiovascular risks for individuals with pre-existing heart disease.

Partially SupportedA low-stress environment with good sleep and infrared light exposure can increase HRV.

Partially SupportedMethylated B vitamins are generally safe and effective for methylation support, though some individuals may react negatively.

Partially SupportedCertain unique nutrients and genetic factors can resolve many neuropsychiatric issues.

Partially SupportedSweating and electrolyte loss in hot climates can lead to heart palpitations and thyroid issues.

Partially SupportedTo achieve weight loss, improve food quality and consider reducing the intensity or frequency of intense workouts.

Partially SupportedWeight loss is primarily achieved by improving food quality, which affects basal metabolism, rather than focusing on calories in versus calories out.

Limited ResearchHaving fruit available year-round without breaks may be a concern from a quantum biology perspective due to continuous electron donation to mitochondrial complex I, potentially producing superoxide and leading to glycation and issues with autophagy.

Partially SupportedA strict carnivore diet can lead to higher fasting blood sugar levels (95-100) due to elevated glucagon and catecholamines.

Partially SupportedPaul Saladino's fasting blood sugar is typically lower on an animal-based diet than on a strict carnivore diet.

Partially SupportedA trial of methylated B vitamins, including methylfolate (~1mg) and TMG (~600mg), is suggested for individuals experiencing anxiety.

Partially SupportedAligning modern living with innate human biology leads to thriving.

Partially SupportedAn excellent nutrition education can be obtained for free by listening to podcast archives and finding good health bloggers, assuming basic biochemistry knowledge.

Partially SupportedMany beneficial nutrients for longevity are found exclusively or predominantly in animal foods.

Not SupportedMonocrop agriculture worsens ecological metrics, including soil health, water infiltration, and biodiversity, in contrast to grazing practices.

Partially SupportedShifting dietary fat to more saturated and less polyunsaturated fat may increase ApoB but is often accompanied by favorable changes like decreased triglycerides and increased HDL.

Partially SupportedThe ABNRF plans to test heavy metals in salts, compare nutrient analysis of grass-fed versus grain-fed meat, and investigate glyphosate in honey and meats.

Partially SupportedBringing personal cooking fats like tallow or coconut oil to restaurants may be a viable strategy for healthier eating.

Partially SupportedOlive oil is a fruit oil, not a seed oil.

Partially SupportedElevated fasting blood sugar levels after HIIT workouts may be normal and related to muscle growth and recovery.

Partially SupportedLiver is the primary organ meat source of copper, while muscle meat contains little copper.

Partially SupportedElevated DHEA blood marker levels may indicate impaired conversion or downstream processing.

Not SupportedThere is no such thing as vegan collagen.

Partially SupportedInfrared light deficiency may be a concern for humans.

Limited ResearchDehydration and potentially excessive sauna use may contribute to gout.

Partially SupportedElectrolyte balance is individualized and depends on factors like gut health.